Modulation of Lipid Metabolism by Celastrol

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Modulation of Lipid Metabolism by Celastrol
	Zhang, Ting 1,2; Zhao, Qi1,2 ; Xiao, Xuerong 1; Yang, Rui 1,2; Hu, Dandan 1; Zhu, Xu 1,2; Gonzalez, Frank J.3; Li, Fei 1,4
刊名	JOURNAL OF PROTEOME RESEARCH
	2019-03-01
卷号	18 期号:3 页码:1133-1144
关键词	celastrol lipidomics hyperlipidemia LC-MS
ISSN号	1535-3893
英文摘要	Hyperlipidemia, characterized by high serum lipids, is a risk factor for cardiovascular disease. Recent studies have identified an important role for celastrol, a proteasome inhibitor isolated from Tripterygium wilfordii Hook. F., in obesity-related metabolic disorders. However, the exact influences of celastrol on lipid metabolism remain largely unknown. Celastrol inhibited the terminal differentiation of 3T3-L1 adipocytes and decreased the levels of triglycerides in wild-type mice. Lipidomics analysis revealed that celastrol increased the metabolism of lysophosphatidylcholines (LPCs), phosphatidylcholines (PCs), sphingomyelins (SMs), and phosphatidylethanolamines (PEs). Further, celastrol reversed the tyloxapol-induced hyperlipidemia induced associated with increased plasma LPCs, PCs, SMs, and ceramides (CMs). Among these lipids, LPC(16:0), LPC(18:1), PC(22:2/15:0), and SM(d18:1/22:0) were also decreased by celastrol in cultured 3T3-L1 adipocytes, mice, and tyloxapol-treated mice. The mRNAs encoded by hepatic genes associated with lipid synthesis and catabolism, including Lpcat1, Pld1, Smpd3, and Sptc2, were altered in tyloxapol-induced hyperlipidemia, and significantly recovered by celastrol treatment. The effect of celastrol on lipid metabolism was significantly reduced in Fxr-null mice, resulting in decreased Cers6 and Acer2 mRNAs compared to wild-type mice. These results establish that FXR was responsible in part for the effects of celastrol in controlling lipid metabolism and contributing to the recovery of aberrant lipid metabolism in obesity-related metabolic disorders.
语种	英语
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/65199]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Li, Fei
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA 4.Jiangxi Univ Tradit Chinese Med, Nanchang 330004, Jiangxi, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ting,Zhao, Qi,Xiao, Xuerong,et al. Modulation of Lipid Metabolism by Celastrol[J]. JOURNAL OF PROTEOME RESEARCH,2019,18(3):1133-1144.
APA	Zhang, Ting.,Zhao, Qi.,Xiao, Xuerong.,Yang, Rui.,Hu, Dandan.,...&Li, Fei.(2019).Modulation of Lipid Metabolism by Celastrol.JOURNAL OF PROTEOME RESEARCH,18(3),1133-1144.
MLA	Zhang, Ting,et al."Modulation of Lipid Metabolism by Celastrol".JOURNAL OF PROTEOME RESEARCH 18.3(2019):1133-1144.