Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans
	Wang, Wen-Xuan 1; Lei, Xinxiang 1; Ai, Hong-Lian 1; Bai, Xue 2; Li, Jing1 ; He, Juan 1; Li, Zheng-Hui 1; Zheng, Yong-Sheng 1; Feng, Tao 1; Liu, Ji-Kai 1
刊名	ORGANIC LETTERS
	2019-02-15
卷号	21 期号:4 页码:1108-1111
ISSN号	1523-7060
英文摘要	Curtachalasins C-E (1-3), which have an unprecedent bridged 6/6/6/6 ring system, were identified from the endophytic fungus Xylaria cf. curta. Residual dipolar coupling analyses associating with density functional theory calculations were utilized to determine the relative configuration of noncrystallizable compound 2. The absolute configurations of 1-3 were determined by X-ray diffraction and electronic circular dichroism calculations. Remarkably, curtachalasin C (1) showed significant resistance reversal activity against fluconazole-resistant Candida albicans.
资助项目	National Natural Science Foundation of China[31801789] ; National Natural Science Foundation of China[31560010] ; National Natural Science Foundation of China[31870513] ; National Natural Science Foundation of China[81872762] ; National Natural Science Foundation of China[81773590] ; National Natural Science Foundation of China[81561148013] ; National Natural Science Foundation of China[21502239] ; National Natural Science Foundation of China[81803395] ; National Key RD Plan[2017YFC1704007] ; South-Central University for Nationalities
语种	英语
资助机构	National Natural Science Foundation of China ; National Key RD Plan ; South-Central University for Nationalities
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/64598]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Ai, Hong-Lian; Feng, Tao; Liu, Ji-Kai
作者单位	1.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Wang, Wen-Xuan,Lei, Xinxiang,Ai, Hong-Lian,et al. Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans[J]. ORGANIC LETTERS,2019,21(4):1108-1111.
APA	Wang, Wen-Xuan.,Lei, Xinxiang.,Ai, Hong-Lian.,Bai, Xue.,Li, Jing.,...&Liu, Ji-Kai.(2019).Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans.ORGANIC LETTERS,21(4),1108-1111.
MLA	Wang, Wen-Xuan,et al."Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans".ORGANIC LETTERS 21.4(2019):1108-1111.