Cytotoxic Effects of Compounds Isolated from Ricinodendron heudelotii

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Cytotoxic Effects of Compounds Isolated from Ricinodendron heudelotii
	Yakubu, Omolara F.1,2; Adebayo, Abiodun H.1; Dokunmu, Titilope M.1; Zhang, Ying-Jun2 ; Iweala, Emeka E. J.1
刊名	MOLECULES
	2019
卷号	24 期号:1 页码:11
关键词	anticancer Ricinodendron heudelotii chemoprevention
ISSN号	1420-3049
英文摘要	This study was designed to explore the in vitro anticancer effects of the bioactive compounds isolated from Ricinodendron heudelotii on selected cancer cell lines. The leaves of the plant were extracted with ethanol and partitioned in sequence with petroleum ether, ethyl acetate, and n-butanol. The ethyl acetate fraction was phytochemically studied using thin layer chromatography (TLC) and column chromatography (CC). Structural elucidation of pure compounds obtained from the ethyl acetate fraction was done using mass spectra, H-1-NMR, and C-13-NMR analysis. The isolated compounds were subsequently screened using five different cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7, SW-480, and normal lung epithelial cell line, BEAS-2B, to assess their cytotoxic effects. Nine compounds were isolated and structurally elucidated as gallic acid, gallic acid ethyl ester, corilagin, quercetin-3-O-rhamnoside, myricetin-3-O-rhamnoside, 1,4,6-tri-O-galloyl glucose, 3,4,6-tri-O-galloyl glucose, 1,2,6-tri-O-galloyl glucose, and 4,6-di-O-galloyl glucose. Corilagin exhibited the most cytotoxic activity with an IC50 value of 33.18 g/mL against MCF-7 cells, which were comparable to cisplatin with an IC50 value of 27.43 mu g/mL. The result suggests that corilagin isolated from R. heudelotii has the potential to be developed as an effective therapeutic agent against the growth of breast cancer cells.
资助项目	National Natural Science Foundation of China[31470429] ; OWSD Postgraduate Fellowship ; Covenant University Centre for Research Innovation and Discovery (CUCRID)
语种	英语
资助机构	National Natural Science Foundation of China ; OWSD Postgraduate Fellowship ; Covenant University Centre for Research Innovation and Discovery (CUCRID)
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/64410]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Adebayo, Abiodun H.; Zhang, Ying-Jun
作者单位	1.Covenant Univ, Coll Sci & Technol, Dept Biochem, PMB 1023, Ota, Ogun State, Nigeria 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Yakubu, Omolara F.,Adebayo, Abiodun H.,Dokunmu, Titilope M.,et al. Cytotoxic Effects of Compounds Isolated from Ricinodendron heudelotii[J]. MOLECULES,2019,24(1):11.
APA	Yakubu, Omolara F.,Adebayo, Abiodun H.,Dokunmu, Titilope M.,Zhang, Ying-Jun,&Iweala, Emeka E. J..(2019).Cytotoxic Effects of Compounds Isolated from Ricinodendron heudelotii.MOLECULES,24(1),11.
MLA	Yakubu, Omolara F.,et al."Cytotoxic Effects of Compounds Isolated from Ricinodendron heudelotii".MOLECULES 24.1(2019):11.