Protein C receptor stimulates multiple signaling pathways in breast cancer cells | |
Wang, Daisong1; Liu, Chunye1; Wang, Jingqiang1; Jia, Yingying1; Zeng, Yi Arial1; Hu, Xin2; Shao, Zhi-ming2; Jiang, Hai3 | |
刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY |
2018 | |
卷号 | 293期号:4页码:1413-1424 |
关键词 | Hematopoietic Stem-cells Activated Receptor-1 Growth-factor In-vivo Identification Anticoagulant Expression Migration Promote Epcr |
ISSN号 | 0021-9258 |
DOI | 10.1074/jbc.M117.814046 |
文献子类 | Article |
英文摘要 | The protein C receptor (PROCR) has emerged as a stem cell marker in several normal tissues and has also been implicated in tumor progression. However, the functional role of PROCR and the signaling mechanisms downstream of PROCR remain poorly understood. Here, we dissected the PROCR signaling pathways in breast cancer cells. Combining protein array, knockdown, and overexpression methods, we found that PROCR concomitantly activates multiple pathways. We also noted that PROCR-dependent ERK and PI3k-Akt-mTOR signaling pathways proceed through Src kinase and transactivation of insulin-like growth factor 1 receptor (IGF-1R). These pathway activities led to the accumulation of c-Myc and cyclin D1. On the other hand, PROCR-dependent RhoA-ROCK-p38 signaling relied on coagulation factor II thrombin receptor (F2R). We confirmed these findings in primary cells isolated from triple-negative breast cancer-derived xenografts (PDX) that have high expression of PROCR. To the best our knowledge, this is the first comprehensive study of PROCR signaling in breast cancer cells, and its findings also shed light on the molecular mechanisms of PROCR in stem cells in normal tissue. |
电子版国际标准刊号 | 1083-351X |
WOS研究方向 | Biochemistry & Molecular Biology |
语种 | 英语 |
WOS记录号 | WOS:000423515000026 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/3454] |
专题 | 生化所2018年发文 上海生化细胞研究所_上海生科院生化细胞研究所 |
通讯作者 | Zeng, Yi Arial; Shao, Zhi-ming |
作者单位 | 1.Chinese Acad Sci, Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol, Shanghai 200031, Peoples R China; 2.Fudan Univ, Key Lab Breast Canc Shanghai, Dept Breast Surg, Shanghai Canc Ctr,Dept Oncol,Shanghai Med Coll, Shanghai 200032, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Innovat Ctr Cell Signaling Network, Key Lab Syst Biol,Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Daisong,Liu, Chunye,Wang, Jingqiang,et al. Protein C receptor stimulates multiple signaling pathways in breast cancer cells[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2018,293(4):1413-1424. |
APA | Wang, Daisong.,Liu, Chunye.,Wang, Jingqiang.,Jia, Yingying.,Zeng, Yi Arial.,...&Jiang, Hai.(2018).Protein C receptor stimulates multiple signaling pathways in breast cancer cells.JOURNAL OF BIOLOGICAL CHEMISTRY,293(4),1413-1424. |
MLA | Wang, Daisong,et al."Protein C receptor stimulates multiple signaling pathways in breast cancer cells".JOURNAL OF BIOLOGICAL CHEMISTRY 293.4(2018):1413-1424. |
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