PRDM4 mediates YAP-induced cell invasion by activating leukocyte-specific integrin beta 2 expression | |
Liu, Huan1,2; Dai, Xiaoming1,2; Cao, Xiaolei1,2; Yan, Huan1,2; Ji, Xinyan1,2; Zhang, Haitao1,2; Shen, Shuying1,2; Si, Yuan1,2; Feng, Xin-Hua1,2; Zhao, Bin1,2 | |
刊名 | EMBO REPORTS |
2018 | |
卷号 | 19期号:6页码:- |
关键词 | Yes-associated Protein Histone Methyltransferase Complex Hippo Signaling Pathway Organ Size Control Transcription Factor Prostate-cancer Tissue Homeostasis Gene-expression Growth-control Myeloid Cells |
ISSN号 | 1469-221X |
DOI | 10.15252/embr.201745180 |
文献子类 | Article |
英文摘要 | Yes-associated protein (YAP) is a transcriptional co-activator and a major effector of the Hippo pathway that promotes cell proliferation and stemness, while inhibiting apoptosis. YAP plays a central role in organ size control, and its deregulation strongly promotes cancer initiation and progression. However, the mechanisms by which YAP promotes cell invasion and metastasis are not fully understood. Here, we report that YAP induces leukocyte-specific integrin 2 (ITGB2) expression in cancer cells, thereby promoting cell invasion through the endothelium in a manner mimicking leukocytes. Through independent biochemical purification and a functional screen, we further identified PR/SET domain 4 (PRDM4) as a transcription factor interacting with the WW domains of YAP to mediate ITGB2 expression and cell invasion. Consistently, ITGB2 and PRDM4 mRNA levels are significantly increased in metastatic prostate cancer. In addition, PRDM4 contributes to YAP-induced tumorigenesis possibly via mediating the expression of other YAP target genes. Our results demonstrate that YAP promotes cell invasion by inducing leukocyte-specific integrin expression, and identify PRDM4 as a novel transcription factor for YAP targets. |
电子版国际标准刊号 | 1469-3178 |
WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
语种 | 英语 |
WOS记录号 | WOS:000434352400005 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/3453] |
专题 | 生化所2018年发文 |
通讯作者 | Zhao, Bin |
作者单位 | 1.Zhejiang Univ, Life Sci Inst, Hangzhou, Zhejiang, Peoples R China; 2.Zhejiang Univ, Innovat Ctr Cell Signaling Network, Hangzhou, Zhejiang, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol,Inst Biochem & Cell Biol, Shanghai, Peoples R China; 4.Hangzhou Normal Univ, Inst Aging Res, Hangzhou, Zhejiang, Peoples R China; 5.Northwestern Univ, Feinberg Sch Med, Robert H Lurie Comprehens Canc Ctr, Dept Med Hematol Oncol, Chicago, IL 60611 USA |
推荐引用方式 GB/T 7714 | Liu, Huan,Dai, Xiaoming,Cao, Xiaolei,et al. PRDM4 mediates YAP-induced cell invasion by activating leukocyte-specific integrin beta 2 expression[J]. EMBO REPORTS,2018,19(6):-. |
APA | Liu, Huan.,Dai, Xiaoming.,Cao, Xiaolei.,Yan, Huan.,Ji, Xinyan.,...&Yu, Jindan.(2018).PRDM4 mediates YAP-induced cell invasion by activating leukocyte-specific integrin beta 2 expression.EMBO REPORTS,19(6),-. |
MLA | Liu, Huan,et al."PRDM4 mediates YAP-induced cell invasion by activating leukocyte-specific integrin beta 2 expression".EMBO REPORTS 19.6(2018):-. |
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