Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice | |
Yang, Wenjuan1; Zhou, Keyan1,2; Zhou, Yue1; An, Yuqian1; Hu, Tingting1; Lu, Jing1; Pei, Gang1,4; Huang, Shichao3 | |
刊名 | FRONTIERS IN AGING NEUROSCIENCE |
2018 | |
卷号 | 10期号:1页码:- |
关键词 | Adult Hippocampal Neurogenesis A-beta Levels Alzheimers-disease Vitamin-e Amyloid Deposition Mouse Model Curcumin Memory Trial Neuroinflammation |
ISSN号 | 1663-4365 |
DOI | 10.3389/fnagi.2018.00169 |
文献子类 | Article |
英文摘要 | Alzheimer's disease (AD) is a multi-factorial neurodegenerative disorder with abnormal accumulation of amyloid-beta (A beta) plaques, neuroinflammation and impaired neurogenesis. Mounting evidences suggest that single-target drugs have limited effects on clinical treatment and alternative or multiple targets are required. In recent decades, natural compounds and their derivatives have gained increasing attention in AD drug discovery due to their inherently enormous chemical and structural diversity. In this study, we demonstrated that naringin dihydrochalcone (NDC), a widely used dietary sweetener with strong antioxidant activity, improved the cognitive function of transgenic AD mice. Pathologically, NDC attenuated A beta deposition in AD mouse brain. Furthermore, NDC reduced periplaque activated microglia and astrocytes, indicating the inhibition of neuroinflammation. It also enhanced neurogenesis as investigated by BrdU/NeuN double labeling. Additionally, the inhibition of Ab level and neuroinflammation by NDC treatment was also observed in an AD cell model or a microglia cell line. Taken together, our study indicated that NDC might be a potential therapeutic agent for the treatment of AD against multiple targets that include A beta pathology, neuroinflammation and neurogenesis. |
WOS研究方向 | Geriatrics & Gerontology ; Neurosciences |
语种 | 英语 |
WOS记录号 | WOS:000434155000001 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/3445] |
专题 | 生化所2018年发文 |
通讯作者 | Pei, Gang |
作者单位 | 1.Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol,Chinese Acad Sci, Shanghai, Peoples R China; 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China; 3.Tongji Univ, Shanghai Key Lab Signaling & Dis Res, Sch Life Sci & Technol, Lab Receptor Based Biomed, Shanghai, Peoples R China; 4.Tongji Univ, Sch Life Sci & Technol, Collaborat Innovat Ctr Brain Sci, Shanghai, Peoples R China |
推荐引用方式 GB/T 7714 | Yang, Wenjuan,Zhou, Keyan,Zhou, Yue,et al. Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice[J]. FRONTIERS IN AGING NEUROSCIENCE,2018,10(1):-. |
APA | Yang, Wenjuan.,Zhou, Keyan.,Zhou, Yue.,An, Yuqian.,Hu, Tingting.,...&Huang, Shichao.(2018).Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice.FRONTIERS IN AGING NEUROSCIENCE,10(1),-. |
MLA | Yang, Wenjuan,et al."Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice".FRONTIERS IN AGING NEUROSCIENCE 10.1(2018):-. |
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