Inhibition of kinesin family member 20B sensitizes hepatocellular carcinoma cell to microtubule-targeting agents by blocking cytokinesis | |
Liu, Xinran1,2; Zhang, Xia1; Chen, Yuchen1; Meng, Lijing1; Chen, Hong1; Zhang, Yu1; Huang, Kun1,2; Li, Yangkai3; Liu, Xin-Yuan4![]() | |
刊名 | CANCER SCIENCE
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2018 | |
卷号 | 109期号:11页码:3450-3460 |
关键词 | Spindle Assembly Checkpoint Oncogenic Role Breast-cancer Mitotic Exit Liver Paclitaxel Adenocarcinoma Accumulation Suppression Resistance |
ISSN号 | 1349-7006 |
DOI | 10.1111/cas.13794 |
文献子类 | Article |
英文摘要 | Kinesin family member 20B (KIF20B, also known as MPHOSPH1) is a kinesin protein that plays a critical role in cytokinesis. Previously, we and others have demonstrated the oncogenic role of KIF20B in several cancers; however, the exact mechanisms underlying its tumorigenic effects remain unclear. Herein, we showed overexpression of KIF20B in human hepatocellular carcinoma (HCC) and reported a negative correlation between KIF20B level and prognosis of patients. Mechanistically, reducing KIF20B blockades mitotic exit of HCC cells at telophase in a spindle assembly checkpoint independent way. Importantly, reducing KIF20B acts synergistically with three microtubule-associated agents (MTA) to p53- or p14ARF-dependently suppress p53-wt or p53-null HCC cells. In addition to taxol, reducing KIF20B also enhanced the toxicity of two chemotherapeutic drugs, hydroxycamptothecin and mitomycin C. In conclusion, we found a novel mechanism in that blocking cytokinesis by KIF20B inhibition increases the efficacy of MTA; our results thus suggested a dual-mitotic suppression approach against HCC by combining MTA with KIF20B inhibition, which simultaneously blocks mitosis at both metaphase and telophase. |
WOS研究方向 | Oncology |
语种 | 英语 |
WOS记录号 | WOS:000449711400010 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/3426] ![]() |
专题 | 生化所2018年发文 |
通讯作者 | Huang, Kun |
作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Sch Pharm, Wuhan, Hubei, Peoples R China; 2.Wuhan Inst Biotechnol, Ctr Biomed Res, Wuhan, Hubei, Peoples R China; 3.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan, Hubei, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai, Peoples R China; 5.Third Hosp Wuhan, Wuhan, Hubei, Peoples R China; 6.Huazhong Univ Sci & Technol, Tongji Sch Publ Hlth, Wuhan, Hubei, Peoples R China; 7.Wuhan Univ, Coll Life Sci, Wuhan, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Liu, Xinran,Zhang, Xia,Chen, Yuchen,et al. Inhibition of kinesin family member 20B sensitizes hepatocellular carcinoma cell to microtubule-targeting agents by blocking cytokinesis[J]. CANCER SCIENCE,2018,109(11):3450-3460. |
APA | Liu, Xinran.,Zhang, Xia.,Chen, Yuchen.,Meng, Lijing.,Chen, Hong.,...&Zheng, Ling.(2018).Inhibition of kinesin family member 20B sensitizes hepatocellular carcinoma cell to microtubule-targeting agents by blocking cytokinesis.CANCER SCIENCE,109(11),3450-3460. |
MLA | Liu, Xinran,et al."Inhibition of kinesin family member 20B sensitizes hepatocellular carcinoma cell to microtubule-targeting agents by blocking cytokinesis".CANCER SCIENCE 109.11(2018):3450-3460. |
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