Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy | |
Yin, Jie1,2; Yang, Lele1,2; Liu, Yan1; Li, Sheng1; Yang, Wenjun1; Xu, Bo1,2; Ji, Hongbin1; Hu, Ping1,2; Xie, Yangli3; Chen, Lin3 | |
刊名 | NATURE COMMUNICATIONS |
2018 | |
卷号 | 9期号:1页码:1752 |
关键词 | Signaling Pathways Dickkopf Proteins Ubiquitin Ligases Muscular-dystrophy Beta-catenin Stem-cells Mouse Lung In-vivo Foxo Cancer |
ISSN号 | 2041-1723 |
DOI | 10.1038/s41467-018-04038-6 |
文献子类 | Article |
英文摘要 | Age-related muscle atrophy (sarcopenia) is the leading cause for disability in aged population, but the underlying molecular mechanisms are poorly understood. Here we identify a novel role for the secreted glycoprotein Dickkopf 3 (Dkk3) in sarcopenia. Forced expression of Dkk3 in muscles in young mice leads to muscle atrophy. Conversely, reducing its expression in old muscles restores both muscle size and function. Dkk3 induces nuclear import of beta-catenin and enhances its interaction with FoxO3, which in turn activates the transcription of E3 ubiquitin ligase Fbxo32 and Trim63, driving muscle atrophy. These findings suggest that Dkk3 may be used as diagnostic marker and as therapeutic target for age-related muscle atrophy, and reveal a distinct transcriptional control of Fbxo32 and Trim63. |
WOS研究方向 | Multidisciplinary Sciences |
语种 | 英语 |
WOS记录号 | WOS:000431119400004 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/3393] |
专题 | 生化所2018年发文 |
通讯作者 | Hu, Ping |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci,State Key Lab Cel, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 2.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, Shanghai, Peoples R China; 3.Third Mil Med Univ, Daping Hosp, Res Inst Surg,State Key Lab Trauma Burns & Com, Trauma Ctr,Ctr Bone Metab & Repair,Dept Rehabil M, Chongqing 400042, Peoples R China; 4.Soochow Univ, Affiliated Hosp 3, 185 Jvqian Rd, Changzhou 21300, Jiangsu, Peoples R China; 5.Tongji Univ, East Hosp, Sch Med, Dept Neurol, Shanghai 200120, Peoples R China |
推荐引用方式 GB/T 7714 | Yin, Jie,Yang, Lele,Liu, Yan,et al. Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy[J]. NATURE COMMUNICATIONS,2018,9(1):1752. |
APA | Yin, Jie.,Yang, Lele.,Liu, Yan.,Li, Sheng.,Yang, Wenjun.,...&Li, Gang.(2018).Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy.NATURE COMMUNICATIONS,9(1),1752. |
MLA | Yin, Jie,et al."Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy".NATURE COMMUNICATIONS 9.1(2018):1752. |
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