Adenovirus armed with VGLL4 selectively kills hepatocellular carcinoma with G2/M phase arrest and apoptosis promotion | |
Xie, Wenjie1; Hao, Jiali1; Liu, Xinyuan1; Zhang, Kangjian2,3; Liu, Xinyuan2,3; Fang, Xianlong3 | |
刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS |
2018 | |
卷号 | 503期号:4页码:2758-2763 |
关键词 | Oncolytic Adenovirus Cancer Virotherapy Antitumor Efficacy Gastric-cancer Lung-cancer Therapy Potency Protein |
ISSN号 | 0006-291X |
DOI | 10.1016/j.bbrc.2018.08.036 |
文献子类 | Article |
英文摘要 | The Vestigial-Like Family Member 4 (VGLL4) functions as a native inhibitor of cell proliferation and tumor growth through multiple signaling pathways. We first discovered that VGLL4 causes G2/M phase arrest in hepatocellular carcinoma (HCC) cells. Then, we designed a novel survivin-regulated oncolytic adenovirus Ad-sp-VGLL4 carrying the VGLL4 gene. Ad-sp-VGLL4 exerted high HCC-targeting-selectivity but is less harmful to normal cells. This adenovirus construction enhanced antitumor activity due to G2/M phase arrest and enhanced apoptosis. It's also indicated that Ad-sp-VGLL4 could suppress the growth of transplanted tumor of HCC in vivo experiment. Taken together, our results suggest that Ad-sp-VGLL4 possesses strong antitumor capacity and has great potential use for HCC therapy. (C) 2018 Elsevier Inc. All rights reserved. |
电子版国际标准刊号 | 1090-2104 |
WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
语种 | 英语 |
WOS记录号 | WOS:000444791600084 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/3376] |
专题 | 生化所2018年发文 上海生化细胞研究所_上海生科院生化细胞研究所 |
通讯作者 | Xie, Wenjie; Hao, Jiali; Zhang, Kangjian; Liu, Xinyuan |
作者单位 | 1.Zhejiang Sci Tech Univ, Xinyuan Inst Med & Biotechnol, Sch Life Sci, Hangzhou 310018, Zhejiang, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China; 3.Shanghai YuanSong Biol Technol Co Ltd, 1588 Shanghai & Hangzhou Highway, Shanghai 201401, Peoples R China |
推荐引用方式 GB/T 7714 | Xie, Wenjie,Hao, Jiali,Liu, Xinyuan,et al. Adenovirus armed with VGLL4 selectively kills hepatocellular carcinoma with G2/M phase arrest and apoptosis promotion[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018,503(4):2758-2763. |
APA | Xie, Wenjie,Hao, Jiali,Liu, Xinyuan,Zhang, Kangjian,Liu, Xinyuan,&Fang, Xianlong.(2018).Adenovirus armed with VGLL4 selectively kills hepatocellular carcinoma with G2/M phase arrest and apoptosis promotion.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,503(4),2758-2763. |
MLA | Xie, Wenjie,et al."Adenovirus armed with VGLL4 selectively kills hepatocellular carcinoma with G2/M phase arrest and apoptosis promotion".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 503.4(2018):2758-2763. |
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