Preparation of Microgels with Ultrahigh Payload of Various Hydrophilic and Hydrophobic Inorganic Nanoparticle Composites up to 92 wt %

doi:10.1021/acsami.8b20089

	Preparation of Microgels with Ultrahigh Payload of Various Hydrophilic and Hydrophobic Inorganic Nanoparticle Composites up to 92 wt %
	Wang, Anhe; Li, Jieling; Dong, Qianqian; Wang, Shengtao; Jian, Honglei; Wang, Meiyue; Ren, Peng; Bai, Shuo
刊名	ACS APPLIED MATERIALS & INTERFACES
	2019-01-30
卷号	11 期号:4 页码:4408-4415
关键词	microgel encapsulation high payload nanocomposites "casting" strategy
ISSN号	1944-8244
DOI	10.1021/acsami.8b20089
英文摘要	Microgel loading with inorganic nanoparticle (NP) composites attracts interest for various biomedical applications. However, the encapsulation of NPs into microgels usually is a diffusion process driven by osmotic pressure, which depends highly on the concentration of NPs and causes low loading efficiency. In this work, we demonstrate preparation of microgels with ultrahigh content of various nano-objects (up to 92%, wt %) by a gelatin "casting" strategy using porous CaCO3 particles as templates. This approach could encapsulate various NPs with different charged, hydrophilic, and hydrophobic surfaces, shape, and size within microgels, without causing aggregation or change of physicochemical properties of NPs. The hybrid microgels coupled with properties of both inorganic NPs and hydrogels can be taken as an effective photothermal therapy system with great stability, reusability, and degradability and show high effective photothermal activity which is highly related to the content of NPs within microgels. The strategy of fabrication of microgels with nanocomposites is certified to be simple, facile, and low cost, which has potential applications in cancer therapy, drug delivery, catalysis, detecting system, and sewage treatment.
资助项目	National Natural Science Foundation of China[21774132] ; National Natural Science Foundation of China[21703253]
WOS关键词	GOLD NANOPARTICLES ; CONTROLLED-RELEASE ; HYBRID MICROGELS ; AQUEOUS-MEDIA ; QUANTUM DOTS ; NANORODS ; GELATIN ; GLUCOSE ; MICROCAPSULES ; FABRICATION
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000457816900082
资助机构	National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/27843]
专题	中国科学院过程工程研究所
通讯作者	Bai, Shuo
作者单位	Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Wang, Anhe,Li, Jieling,Dong, Qianqian,et al. Preparation of Microgels with Ultrahigh Payload of Various Hydrophilic and Hydrophobic Inorganic Nanoparticle Composites up to 92 wt %[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(4):4408-4415.
APA	Wang, Anhe.,Li, Jieling.,Dong, Qianqian.,Wang, Shengtao.,Jian, Honglei.,...&Bai, Shuo.(2019).Preparation of Microgels with Ultrahigh Payload of Various Hydrophilic and Hydrophobic Inorganic Nanoparticle Composites up to 92 wt %.ACS APPLIED MATERIALS & INTERFACES,11(4),4408-4415.
MLA	Wang, Anhe,et al."Preparation of Microgels with Ultrahigh Payload of Various Hydrophilic and Hydrophobic Inorganic Nanoparticle Composites up to 92 wt %".ACS APPLIED MATERIALS & INTERFACES 11.4(2019):4408-4415.