Effect of lactulose intervention on gut microbiota and short chain fatty acid composition of C57BL/6J mice | |
Zhai, Shixiang1,2; Zhu, Limeng1,2,3; Qin, Song1; Li, Lili1 | |
刊名 | MICROBIOLOGYOPEN |
2018-12-01 | |
卷号 | 7期号:6页码:8 |
关键词 | 16s Rrna High-throughput Sequencing Gut Microbiota Prebiotic Probiotics Short Chain Fatty Acids |
ISSN号 | 2045-8827 |
DOI | 10.1002/mbo3.612 |
英文摘要 | Gut microbiota have strong connections with health. Lactulose has been shown to regulate gut microbiota and benefit host health. In this study, the effect of short-term (3 week) intervention of lactulose on gut microbiota was investigated. Gut microbiota were detected from mouse feces by 16S rRNA high-throughput sequencing, and short chain fatty acids (SCFAs) were detected by gas chromatography-mass spectrometry (GC-MS). Lactulose intervention enhanced the alpha-diversity of the gut microbiota; increased the abundance of hydrogen-producing bacteria Prevotellaceae and Rikenellaceae, probiotics Bifidobacteriaceae and Lactobacillaceae, and mucin-degrading bacteria Akkermansia and Helicobacter; decreased the abundance of harmful bacteria Desulfovibrionaceae and branched-chain SCFAs (BCFAs). These results suggest that lactulose intervention effectively increased the diversity and improved the structure of the intestinal microbiota, which may be beneficial for host health. |
资助项目 | National Key Research and Development plan[2017YFC0506200] ; National Natural Science Foundation of China[21306221] ; Science and Technology Major Project of Shandong Province[2015ZDJS03002] |
WOS关键词 | Relative Organ Weight ; Growth-performance ; Fecal Microbiota ; Diet ; Supplementation ; Fermentation ; Metabolism ; Health ; Lactobacillus ; Alcohol |
WOS研究方向 | Microbiology |
语种 | 英语 |
出版者 | WILEY |
WOS记录号 | WOS:000453616500014 |
资助机构 | National Key Research and Development plan ; National Natural Science Foundation of China ; Science and Technology Major Project of Shandong Province |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/27626] |
专题 | 中国科学院过程工程研究所 |
通讯作者 | Li, Lili |
作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Shandong, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Zhai, Shixiang,Zhu, Limeng,Qin, Song,et al. Effect of lactulose intervention on gut microbiota and short chain fatty acid composition of C57BL/6J mice[J]. MICROBIOLOGYOPEN,2018,7(6):8. |
APA | Zhai, Shixiang,Zhu, Limeng,Qin, Song,&Li, Lili.(2018).Effect of lactulose intervention on gut microbiota and short chain fatty acid composition of C57BL/6J mice.MICROBIOLOGYOPEN,7(6),8. |
MLA | Zhai, Shixiang,et al."Effect of lactulose intervention on gut microbiota and short chain fatty acid composition of C57BL/6J mice".MICROBIOLOGYOPEN 7.6(2018):8. |
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