Three-Dimensional Bioprinting of Articular Cartilage: A Systematic Review

	Three-Dimensional Bioprinting of Articular Cartilage: A Systematic Review
	Aman Dhawan; Yang Wu; Patrick Kennedy; Nicholas Bonazza; Yin Yu; Ibrahim Ozbolat
刊名	cartilage
	2018
文献子类	期刊论文
英文摘要	Objective. Treatment of chondral injury is clinically challenging. Available chondral repair/regeneration techniques have significant shortcomings. A viable and durable tissue engineering strategy for articular cartilage repair remains an unmet need. Our objective was to systematically evaluate the published data on bioprinted articular cartilage with regards to scaffold-based, scaffold-free and in situ cartilage bioprinting. Design. We performed a systematic review of studies using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed and ScienceDirect databases were searched and all articles evaluating the use of 3-dimensional (3D) bioprinting in articular cartilage were included. Inclusion criteria included studies written in or translated to English, published in a peer-reviewed journal, and specifically discussing bioinks and/or bioprinting of living cells related to articular cartilage applications. Review papers, articles in a foreign language, and studies not involving bioprinting of living cells related to articular cartilage applicationswere excluded. Results. Twenty-seven studies for articular cartilage bioprinting were identified that met inclusion and exclusion criteria. The technologies, materials, cell types used in these studies, and the biological and physical properties of the created constructs have been demonstrated. Conclusion. These 27 studies have demonstrated 3D bioprinting of articular cartilage to be a tissue engineering strategy that has tremendous potential translational value. The unique abilities of the varied techniques allow replication of mechanical properties and advances toward zonal differentiation. This review demonstrates that bioprinting has great capacity for clinical cartilage reconstruction and future in vivo implantation
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/13453]
专题	合成所
推荐引用方式 GB/T 7714	Aman Dhawan,Yang Wu,Patrick Kennedy,et al. Three-Dimensional Bioprinting of Articular Cartilage: A Systematic Review[J]. cartilage,2018.
APA	Aman Dhawan,Yang Wu,Patrick Kennedy,Nicholas Bonazza,Yin Yu,&Ibrahim Ozbolat.(2018).Three-Dimensional Bioprinting of Articular Cartilage: A Systematic Review.cartilage.
MLA	Aman Dhawan,et al."Three-Dimensional Bioprinting of Articular Cartilage: A Systematic Review".cartilage (2018).