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	Targeted Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-Tumor Immunity and Abscopal Effect
	Haimei Zhou; Mingbin Zheng; Lintao Cai; Zhikuan Chen; Ruijing Liang; Huamei He; Lanlan Liu
	2018
会议日期	2018
会议地点	上海
英文摘要	An ideal cancer therapeutic strategy is expected to possess potent ability that not only can ablate the primary tumor, but also can prevent the distance metastasis and relapse [1]. Herein, chlorine e6 (Ce6) loaded human serum albumin (HSA)/hemoglobin (Hb) hybrid protein oxygen nanocarrier (C@HPOC) were developed via intermolecular disulfide conjugation to apply as oxygen self-sufficient nanophotosensitizers [2]. Benefited from the HSA-targeting delivery of oxygen and photosensitizer [3], C@HPOC not only relieved tumor hypoxia and produced massive reactive oxygen species (ROS) under laser irradiation to boost the PDT efficacy, but also elicited immunogenic cell death (ICD) with danger-associated molecular patterns (DAMPs) release to promote the maturation of dendritic cells (DCs) and subsequent activation of T lymphocytes and natural killer cells. Our results revealed that C@HPOC-mediated immunogenic PDT can directly destroy the primary tumors, and further suppress the distant tumors and prevent the lung metastasis in a metastatic triple-negative breast cancer (TNBC) model by stimulating strong and systemic anti-tumor immune responses. This study provides a new paradigm of oxygen-augmented immunogenic PDT for advanced or metastatic TNBC treatment.
语种	英语
内容类型	会议论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14750]
专题	深圳先进技术研究院_医药所
推荐引用方式 GB/T 7714	Haimei Zhou,Mingbin Zheng,Lintao Cai,et al. Targeted Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-Tumor Immunity and Abscopal Effect[C]. 见:. 上海. 2018.

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