Targeted delivery of doxorubicin by CSA-binding nanoparticles for choriocarcinoma treatment.

	Targeted delivery of doxorubicin by CSA-binding nanoparticles for choriocarcinoma treatment.
	Zhang, Baozhen; Cheng, Guogang; Zheng, Mingbin; Han, Jinyu; Wang, Baobei; Li, Mengxia; Chen, Jie; Xiao, Tianxia; Zhang, Jian; Cai, Lintao
刊名	DRUG DELIVERY
	2018
文献子类	期刊论文
英文摘要	Gestational trophoblastic neoplasia (GTN) can result from the over-proliferation of trophoblasts. Treatment of choriocarcinoma, the most aggressive GTN, currently requires high doses of systemic chemotherapeutic agents, which result in indiscriminate drug distribution and severe toxicity. To overcome these disadvantages and enhance the chemotherapeutic efficacy, chondroitin sulfate A (CSA)-binding nanoparticles were developed for the targeted delivery of doxorubicin (DOX) to choriocarcinoma cells using a synthetic CSA-binding peptide (CSA-BP), derived from malarial protein, which specifically binds to the CSA exclusively expressed in the placental trophoblast. CSA-BP-conjugated nanoparticles rapidly bonded to choriocarcinoma (JEG3) cells and were efficiently internalized into the lysosomes. Moreover, CSA-BP modification significantly increased the anti-cancer activity of the DOX-loaded nanoparticles in vitro. Intravenous injections of CSA-BP-conjugated nanoparticles loaded with indocyanine green (CSA-INPs) were rapidly localized to the tumor. The CSA-targeted nanoparticles loaded with DOX (CSA-DNPs) strongly inhibited primary tumor growth and, more importantly, significantly suppressed metastasis in vivo. Collectively, our results highlight the potential of the CSA-BP-decorated nanoparticles as an alternative targeted delivery system ofchemotherapeutic agents for treating choriocarcinoma and for developing new GTN therapies based on drug targeting.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14688]
专题	深圳先进技术研究院_医药所
推荐引用方式 GB/T 7714	Zhang, Baozhen,Cheng, Guogang,Zheng, Mingbin,et al. Targeted delivery of doxorubicin by CSA-binding nanoparticles for choriocarcinoma treatment.[J]. DRUG DELIVERY,2018.
APA	Zhang, Baozhen.,Cheng, Guogang.,Zheng, Mingbin.,Han, Jinyu.,Wang, Baobei.,...&Fan, Xiujun.(2018).Targeted delivery of doxorubicin by CSA-binding nanoparticles for choriocarcinoma treatment..DRUG DELIVERY.
MLA	Zhang, Baozhen,et al."Targeted delivery of doxorubicin by CSA-binding nanoparticles for choriocarcinoma treatment.".DRUG DELIVERY (2018).