A self-assembling method to prepare lactoferrin nanoparticles for photosensitizer delivery

	A self-assembling method to prepare lactoferrin nanoparticles for photosensitizer delivery
	Guanjun Deng; Sanpeng Li; Ting Zhu; Ping Gong; Lintao Cai
刊名	Nanomedicine: Nanotechnology, Biology and Medicine
	2018
文献子类	会议论文
英文摘要	Protein-based nanoparticles hold great application in both preclinical and clinical due to their high biocompatibility and biodegradability. The present work deals with the design and process optimization for preparation of lactoferrin nanoparticles as carrier for delivery of photosensitizer to treat tumor. Lactoferrin (LF) and photosensitizer (ICG) were mixed with 50 mM GSH at 37 °C for 1 h to break disul fide bonds. Then, 2 mL of the ethanol was added into the solution to precipitate the LF-ICGNPs and kept under stirring for 30 min. The suspension was dialyzed. Using this method, LF-ICGNPs could be readily obtained. The hydrodynamic size of LF-ICGNPs was 130 nm with polydispersity of 0.100-0.150. The absorption spectra displayed that ICG was encapsulated in LF-ICGNPs. ICG absorbed NIR light and converted it into cytotoxic heat for tumor. Therefore, LF-ICGNPs can provide a noninvasive assistant tool for cancer phototherapy.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14629]
专题	深圳先进技术研究院_医药所
推荐引用方式 GB/T 7714	Guanjun Deng,Sanpeng Li,Ting Zhu,et al. A self-assembling method to prepare lactoferrin nanoparticles for photosensitizer delivery[J]. Nanomedicine: Nanotechnology, Biology and Medicine,2018.
APA	Guanjun Deng,Sanpeng Li,Ting Zhu,Ping Gong,&Lintao Cai.(2018).A self-assembling method to prepare lactoferrin nanoparticles for photosensitizer delivery.Nanomedicine: Nanotechnology, Biology and Medicine.
MLA	Guanjun Deng,et al."A self-assembling method to prepare lactoferrin nanoparticles for photosensitizer delivery".Nanomedicine: Nanotechnology, Biology and Medicine (2018).