Enhanced drug delivery using sonoactivatable liposomes with membrane-embedded porphyrins

	Enhanced drug delivery using sonoactivatable liposomes with membrane-embedded porphyrins
	Sheng, Zonghai; Sun, Yue; Wang, Pan; Liu, Xiufang; Yan, Fei; Zheng, Hairong; Lovell, Jonathan F.; Shao, Shuai; Wang, Xiaobing; Liu, Quanhong
刊名	JOURNAL OF CONTROLLED RELEASE
	2018
文献子类	期刊论文
英文摘要	Small molecules that interfere with nucleic acid are widely used in chemotherapy, however, improved delivery approaches are required to improve anti-tumor outcomes. Here, we present the development of an ultrasound-activatable porphyrin-phospholipid-liposome (pp-lipo) that responds to low intensity focused ultrasound (LIFU) for sonodynamic therapy (SDT). The pp-lipo is constructed by incorporating a small proportion of porphyrin (pyropheophorbide) conjugated lipid into a liposome formulation. This enables sonosensitization-induced lipid oxidation and efficient disruption of liposomes to release loaded doxorubicin (Dox). This results in increased Dox nuclear subcellular location and cytotoxicity in cancer cells in vitro upon pp-lipo exposure to LIFU. Following intravenous administration, LIFU enhanced deposition of Dox within tumor tissue, suppressed tumor growth, and also increased porphyrin near infrared tumor fluorescence. Thus, pp-lipo is a versatile carrier that can be extended to many ultrasound-controllable drug delivery applications.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14343]
专题	深圳先进技术研究院_医工所
推荐引用方式 GB/T 7714	Sheng, Zonghai,Sun, Yue,Wang, Pan,et al. Enhanced drug delivery using sonoactivatable liposomes with membrane-embedded porphyrins[J]. JOURNAL OF CONTROLLED RELEASE,2018.
APA	Sheng, Zonghai.,Sun, Yue.,Wang, Pan.,Liu, Xiufang.,Yan, Fei.,...&Liu, Quanhong.(2018).Enhanced drug delivery using sonoactivatable liposomes with membrane-embedded porphyrins.JOURNAL OF CONTROLLED RELEASE.
MLA	Sheng, Zonghai,et al."Enhanced drug delivery using sonoactivatable liposomes with membrane-embedded porphyrins".JOURNAL OF CONTROLLED RELEASE (2018).