Highly Stable Conjugated Polymer Dots as Multifunctional Agents for Photoacoustic Imaging-Guided Photothermal Therapy.

	Highly Stable Conjugated Polymer Dots as Multifunctional Agents for Photoacoustic Imaging-Guided Photothermal Therapy.
	Qi, Qiaofang; Gao, Duyang; Wang, Yating; Li, Dongliang; Zheng, Hairong; Zhang, Xuanjun; Sheng, Zonghai; Yuan, Zhen; Chang, Kaiwen; Liu, Yubin
刊名	ACS APPLIED MATERIALS & INTERFACES
	2018
文献子类	期刊论文
英文摘要	Theranostic nanomedicines involved in photothermal therapy (PTT) have received constant attention as promising alternatives to traditional therapies in clinic. However, most photothermal agents are limited by their instability and low photothermal conversion efficiency. In this study, we report new conjugated polymer dots (Pdots) as multifunctional agents for photoacoustic (PA) imaging-guided PTT. The novel 4,8-bis [5-(2-ethylhexyl)thiophen-2-yl]-2,6-bis(trimethylstannyl)benzo [1,2-b:4,5-b']dithiophene-6,6'-dibromo-N,N'-(2-ethylhexyl)isoindigo (BDT-IID) Pdots are readily fabricated though nanoreprecipitation and can absorb strongly in the 650-700 nm region. Furthermore, the BDT-IID Pdots possess a stable nanostructure and an extremely low biotoxicity. In particular, its photothermal conversion efficiency can be up to 45%. More importantly, our in vivo results exhibit that the BDT-IID Pdots are able to offer concurrently enhanced PA contrast and sufficient photothermal effect. Consequently, the BDT-IID Pdots can be exploited as a unique theranostic nanoplatform for PA imaging-guided PTT of tumors, holding great promise for their clinical translational development.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14313]
专题	深圳先进技术研究院_医工所
推荐引用方式 GB/T 7714	Qi, Qiaofang,Gao, Duyang,Wang, Yating,et al. Highly Stable Conjugated Polymer Dots as Multifunctional Agents for Photoacoustic Imaging-Guided Photothermal Therapy.[J]. ACS APPLIED MATERIALS & INTERFACES,2018.
APA	Qi, Qiaofang.,Gao, Duyang.,Wang, Yating.,Li, Dongliang.,Zheng, Hairong.,...&Hu, Dehong.(2018).Highly Stable Conjugated Polymer Dots as Multifunctional Agents for Photoacoustic Imaging-Guided Photothermal Therapy..ACS APPLIED MATERIALS & INTERFACES.
MLA	Qi, Qiaofang,et al."Highly Stable Conjugated Polymer Dots as Multifunctional Agents for Photoacoustic Imaging-Guided Photothermal Therapy.".ACS APPLIED MATERIALS & INTERFACES (2018).