Immunomodulatory Effects of Calcium and Strontium Co-Doped Titanium Oxides on Osteogenesis

doi:10.3389/fimmu.2017.01196

	Immunomodulatory Effects of Calcium and Strontium Co-Doped Titanium Oxides on Osteogenesis
	Yuan, Xiangwei ; Cao, Huiliang 1; Wang, Jiaxing ; Tang, Kaiwei 1; Li, Bin ; Zhao, Yaochao ; Cheng, Mengqi ; Qin, Hui ; Liu, Xuanyong 1; Zhang, Xianlong
刊名	FRONTIERS IN IMMUNOLOGY
	2017
卷号	8
ISSN号	1664-3224
DOI	10.3389/fimmu.2017.01196
英文摘要	The effects of calcium (Ca) or strontium (Sr) on host osteogenesis and immune responses have been investigated separately. In clinical practice, these two elements may both be present around an orthopedic device, but their potential synergistic effects on osteogenesis and the immune response have not been explored to date. In this work, we investigated the immunomodulatory effects of Ca and Sr co-doped titanium oxides on osteogenesis in vitro using the mouse macrophage cell line RAW 264.7 alone and in co-culture with mouse bone mesenchymal stem cells (BMSCs), and in vivo using a mouse air-pouch model. Coatings containing Ca and Sr at different concentration ratios were fabricated on titanium substrates using micro-arc oxidation and electrochemical treatment. The in vitro and in vivo results demonstrated that the Ca and Sr concentration ratio has a marked influence on macrophage polarization. The coating with a Ca/Sr ratio of 2: 1 was superior to those with other Ca and/or Sr concentrations in terms of modulating M2 polarization, which enhanced osteogenic differentiation of mouse BMSCs in co-culture. These findings suggest that the osteoimmunomodulatory effect of a titanium-oxide coating can be enhanced by modulating the concentration ratio of its components.
WOS记录号	WOS:000411959100001
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/26642]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Dept Orthoped, Shanghai, Peoples R China 2.Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Xiangwei,Cao, Huiliang,Wang, Jiaxing,et al. Immunomodulatory Effects of Calcium and Strontium Co-Doped Titanium Oxides on Osteogenesis[J]. FRONTIERS IN IMMUNOLOGY,2017,8.
APA	Yuan, Xiangwei.,Cao, Huiliang.,Wang, Jiaxing.,Tang, Kaiwei.,Li, Bin.,...&Zhang, Xianlong.(2017).Immunomodulatory Effects of Calcium and Strontium Co-Doped Titanium Oxides on Osteogenesis.FRONTIERS IN IMMUNOLOGY,8.
MLA	Yuan, Xiangwei,et al."Immunomodulatory Effects of Calcium and Strontium Co-Doped Titanium Oxides on Osteogenesis".FRONTIERS IN IMMUNOLOGY 8(2017).