A comparison of micro-CT and histomorphometry for evaluation of osseointegration of PEO-coated titanium implants in a rat model

doi:10.1038/s41598-017-16465-4

	A comparison of micro-CT and histomorphometry for evaluation of osseointegration of PEO-coated titanium implants in a rat model
	He, Tao ; Cao, Cong ; Xu, Zhiguo ; Li, Gen ; Cao, Huiliang 1; Liu, Xuanyong 1; Zhang, Chao ; Dong, Yuqi
刊名	SCIENTIFIC REPORTS
	2017
卷号	7
ISSN号	2045-2322
DOI	10.1038/s41598-017-16465-4
英文摘要	The aim of the present study was to determine the correlation between bone volume density (BV/TV) around a titanium implant determined by micro-computed tomography (micro-CT) and bone area density (BA/TA) measurements obtained using histomorphometry. An intramedullary rat femur implant model was evaluated to compare raw titanium implants with plasma electrolytic oxidation (PEO)-coated titanium implants. Titanium and PEO-treated titanium pins were inserted into rat femurs under general anesthesia. The animals were sacrificed and femurs harvested at 0, 2, 4 and 6 weeks, and subsequently, histomorphometry and micro-CT were performed. BV/TV and BA/TA values were strongly and positively correlated at all time points and locations (with all correlation coefficients being > 0.8 and with P < 0.001). BV/TV and BA/TA were significantly higher proximal to the growth plate than distal to the growth plate, with estimated differences of 14.10% (P < 0.001) and 11.95% (P < 0.001), respectively. BV/TV and BA/TA were significantly higher on the PEO-coated surface than on the raw titanium surface, with estimated differences of 3.20% (P = 0.044) and 4.10% (P = 0.018), respectively. Therefore, quantitative micro-CT analysis of BV/TV is correlated with BA/TA determined by histomorphometry when artifacts around titanium implants are minimized by a region of interest modification.
WOS记录号	WOS:000416135000069
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/26625]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp, Dept Orthoped, Shanghai 200127, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	He, Tao,Cao, Cong,Xu, Zhiguo,et al. A comparison of micro-CT and histomorphometry for evaluation of osseointegration of PEO-coated titanium implants in a rat model[J]. SCIENTIFIC REPORTS,2017,7.
APA	He, Tao.,Cao, Cong.,Xu, Zhiguo.,Li, Gen.,Cao, Huiliang.,...&Dong, Yuqi.(2017).A comparison of micro-CT and histomorphometry for evaluation of osseointegration of PEO-coated titanium implants in a rat model.SCIENTIFIC REPORTS,7.
MLA	He, Tao,et al."A comparison of micro-CT and histomorphometry for evaluation of osseointegration of PEO-coated titanium implants in a rat model".SCIENTIFIC REPORTS 7(2017).