Combined genotoxicity of chlorinated products from tyrosine and benzophenone-4

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 中国科学院饮用水科学与技术重点实验室

	Combined genotoxicity of chlorinated products from tyrosine and benzophenone-4
	Crittenden, John C.; Liu, Huijuan; Huo, Yang; Bai, Yaohui; Ji, Qinghua; Chang, Yangyang; Qu, Jiuhui
刊名	JOURNAL OF HAZARDOUS MATERIALS
	2017-01-15
卷号	322 期号:0 页码:387-393
关键词	Genotoxicity Combined Effects N-dbps Chlorination Sos/umu Test
英文摘要	The toxicity of disinfection by-products (DBPs) from a single precursor was studied intensively. Here we examined the genotoxicity when two precursors (tyrosine (Tyr) and benzophenone-4 (BP-4)) were chlorinated together and separately. We sought to examine whether the genotoxicity of the mixture (GCM) could be estimated from the sum of the genotoxicities of the individual precursors (GCI), which were chlorinated separately. We determined the genotoxicity using the SOS/umu test. The results revealed that GCM was not identical to GCI. The difference in genotoxicity between GCM and GCI (G(Delta)) was observed to decrease with increasing pH. GCM was higher than GCI (G(Delta) > 0) at pH 5.0-6.1, and lower than GCI (G(Delta) <0) at pH 6.3-8.0. We found that nitrogen-containing DBPs played a dominant role in determining GCM and GCI. We propose that the total organic nitrogen (TON) ratio, TON(chiovinated mixture)/TON(the sum of (chlorinated individuals)) is useful to estimate G(Delta). (C) 2016 Elsevier B.V. All rights reserved.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/39676]
专题	生态环境研究中心_中国科学院饮用水科学与技术重点实验室
推荐引用方式 GB/T 7714	Crittenden, John C.,Liu, Huijuan,Huo, Yang,et al. Combined genotoxicity of chlorinated products from tyrosine and benzophenone-4[J]. JOURNAL OF HAZARDOUS MATERIALS,2017,322(0):387-393.
APA	Crittenden, John C..,Liu, Huijuan.,Huo, Yang.,Bai, Yaohui.,Ji, Qinghua.,...&Qu, Jiuhui.(2017).Combined genotoxicity of chlorinated products from tyrosine and benzophenone-4.JOURNAL OF HAZARDOUS MATERIALS,322(0),387-393.
MLA	Crittenden, John C.,et al."Combined genotoxicity of chlorinated products from tyrosine and benzophenone-4".JOURNAL OF HAZARDOUS MATERIALS 322.0(2017):387-393.