Development of matrix solid-phase dispersion method for the extraction of short-chain chlorinated paraffins in human placenta

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Development of matrix solid-phase dispersion method for the extraction of short-chain chlorinated paraffins in human placenta
	Wu, Jing; Wang, Ying; Gao, Wei; Liu, Huijin; Wang, Yingjun; Wang, Yawei; Jiang, Guibin
刊名	JOURNAL OF ENVIRONMENTAL SCIENCES
	2017-06-07
卷号	62 期号:0 页码:154-162
关键词	Short-chain Chlorinated Paraffins Matrix Solid-phase Dispersion Human Placenta
英文摘要	Chlorinated paraffins (SCCPs) are widely used worldwide, and they can be released into the environment during their production, transport, usage and disposal, which pose potential risks for human health. In this work, an efficient, reliable and rapid pretreatment method based on matrix solid-phase dispersion (MSPD) was developed for the analysis of short-chain CPs (SCCPs) in human placenta by gas chromatograph-electron capture negative ion low-resolution mass spectrometry (GC-ECNI-LRMS) and gas chromatography-quadrupole time-of-flight mass spectrometry (GC-QTOF-HRMS). The MSPD-relevant parameters including dispersing sorbent, sample-to-sorbent mass ratio, and elution solvent were optimized using the orthogonal test. Silica gel was found to be the optimal dispersing sorbent among the selected matrices. Under the optimal conditions, 44% acidic silica gel can be used as the co-sorbent to remove lipid and eluted by the mixture of hexane and dichloromethane (7: 3, V/V). The spiked recoveries of the optimized method were 77.4% and 91.4% for analyzing SCCPs in human placenta by GC-ECNI-LRMS and GC-QTOF-HRMS, and the corresponding relative standard deviations were 10.2% and 5.6%, respectively. The method detection limit for the total SCCPs was 36.8 ng/g (dry weight, dw) and 19.2 ng/g (dw) as measured by GC-ECNI-LRMS and GC-QTOF-HRMS, respectively. The concentrations of SCCPs in four human placentas were in the range of
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/39291]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Wu, Jing,Wang, Ying,Gao, Wei,et al. Development of matrix solid-phase dispersion method for the extraction of short-chain chlorinated paraffins in human placenta[J]. JOURNAL OF ENVIRONMENTAL SCIENCES,2017,62(0):154-162.
APA	Wu, Jing.,Wang, Ying.,Gao, Wei.,Liu, Huijin.,Wang, Yingjun.,...&Jiang, Guibin.(2017).Development of matrix solid-phase dispersion method for the extraction of short-chain chlorinated paraffins in human placenta.JOURNAL OF ENVIRONMENTAL SCIENCES,62(0),154-162.
MLA	Wu, Jing,et al."Development of matrix solid-phase dispersion method for the extraction of short-chain chlorinated paraffins in human placenta".JOURNAL OF ENVIRONMENTAL SCIENCES 62.0(2017):154-162.