Reinforcement attenuation as a behavioral technique to suppress conditioned avoidance response in rats: A comparative study with olanzapine | |
Gao, Jun1,2,3,4; Li, Ming1,4,5 | |
刊名 | JOURNAL OF PSYCHOPHARMACOLOGY |
2019 | |
卷号 | 33期号:1页码:86-100 |
关键词 | Conditioned Avoidance Response Olanzapine Reinforcement Attenuation Extinction Antipsychotic Sensitization |
ISSN号 | 0269-8811 |
DOI | 10.1177/0269881118805497 |
产权排序 | 3 |
文献子类 | Article |
英文摘要 | Background: Antipsychotic treatment is effective in the treatment of psychosis, although it also brings with it some unwanted side effects and is associated with low compliance. Finding a non-pharmacological alternative for antipsychotic treatment is highly desirable. Aims: This preclinical study examined the 'antipsychotic' efficacy of such a behavioral technique using a conditioned avoidance response model. This technique, termed reinforcement attenuation (RA), is to administer a brief footshock (0.1-2.0 s, 0.8 mA) at the end of each trial regardless of whether a well-trained rat makes an avoidance response or not. Results: RA achieved the same avoidance suppressing effect as olanzapine (an atypical antipsychotic drug), including both acute suppression and sensitized suppression of avoidance response in well-trained Sprague-Dawley adult male rats. Interestingly, the RA-induced sensitization (an enhanced disruption of avoidance responding) enhanced subsequent olanzapine sensitivity, whereas the olanzapine (1.0 mg/kg)-induced sensitization had little impact on later RA treatment. When RA and olanzapine (0.5 mg/kg, subcutaneously) were used together, the RA-induced sensitization was still detectable in the RA challenge test, although its magnitude was reduced by olanzapine. Finally, we showed that the RA-induced sensitization in avoidance suppression persisted from adolescence into adulthood, long after such a treatment was terminated. Conclusions: These findings demonstrate that the RA is functionally equivalent (if not superior) to antipsychotic treatment in the avoidance suppression effect (both acute and sensitization effects) in both adolescent and adult animals. Behavioral therapies that specifically target the reinforcer of psychotic thoughts might be a viable strategy for the treatment of psychosis. |
资助项目 | National Institute of Mental Health[5R01MH097718-02] ; National Natural Science Foundation of China (NSFC)[31500891] ; Fundamental Research Funds for the Central Universities[SWU1609131] ; Fundamental Research Funds for the Central Universities[SWU115030] ; Fundamental Research Funds for the Central Universities[SWU116014] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2016G03] ; Chongqing Collaborative Innovation Center for Brain Science, China |
WOS关键词 | Antipsychotic-induced Sensitization ; Dopamine-d-2 Receptor Occupancy ; Risperidone Treatment ; Clozapine Treatment ; Linking Biology ; Animal-models ; Time-course ; Reward ; Schizophrenia ; Extinction |
WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
语种 | 英语 |
出版者 | SAGE PUBLICATIONS LTD |
WOS记录号 | WOS:000456403900008 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/28206] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Gao, Jun; Li, Ming |
作者单位 | 1.Southwest Univ, Fac Psychol, 2 Rd Tiansheng, Chongqing, Peoples R China 2.Southwest Univ, Minist Educ, Key Lab Cognit & Personal, Chongqing, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China 4.Chongqing Collaborat Innovat Ctr Brain Sci, Chongqing, Peoples R China 5.Univ Nebraska, Dept Psychol, 238 Burnett Hall, Lincoln, NE 68588 USA |
推荐引用方式 GB/T 7714 | Gao, Jun,Li, Ming. Reinforcement attenuation as a behavioral technique to suppress conditioned avoidance response in rats: A comparative study with olanzapine[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2019,33(1):86-100. |
APA | Gao, Jun,&Li, Ming.(2019).Reinforcement attenuation as a behavioral technique to suppress conditioned avoidance response in rats: A comparative study with olanzapine.JOURNAL OF PSYCHOPHARMACOLOGY,33(1),86-100. |
MLA | Gao, Jun,et al."Reinforcement attenuation as a behavioral technique to suppress conditioned avoidance response in rats: A comparative study with olanzapine".JOURNAL OF PSYCHOPHARMACOLOGY 33.1(2019):86-100. |
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