Effect of the Tibetan Medicine Zuotai on Degranulation and Inflammatory Mediator Release in RBL-2H3 Cells

	Effect of the Tibetan Medicine Zuotai on Degranulation and Inflammatory Mediator Release in RBL-2H3 Cells
	Shang, Jing 1,2,3,5,6; Wu, Huali 1,2,3; Zou, Xiaoyan 4,5,6; Chen, Haijuan 4,5,6; He, Qiangqiang 4,5,6; Han, Jichun 1,2,3; Wang, Lulu 1,2,3; Du, Yuzhi5,6 ; Wei, Lixin5,6 ; Xia, Zhenjiang 4,5,6
刊名	CHEMICAL & PHARMACEUTICAL BULLETIN
	2018-08-01
卷号	66 期号:8 页码:818-821
关键词	Tibetan Medicine Zuotai Mercury Cytotoxicity Rbl-2h3 Cell
ISSN号	0009-2363
文献子类	Article
英文摘要	Zuotai is a drug containing mercury considered to be the king of Tibetan medicine. The biosafety of Zuotai led people's attention and so far little is known about the toxicity of Zuotai to mast cells. RBL-2H3 cells which used as an alternative model of mast cells were treated with Zuotai, beta-HgS and positive drug Compound 48/80 respectively. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to determine the toxicity of drugs to RBL-2H3 cells. The degranulation of RBL-2H3 cells was studied from beta-hexosaminidase, histamine, interleukin (IL)-4 and tumor necrosis factor-alpha (TNF-alpha). The result showed that Zuotai can affect the cytotoxicity and degranulation of RBL-2H3 cells and the results can provide reference for the toxicity evaluations of Tibetan medicine Zuotai.
WOS关键词	MAST-CELLS
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	PHARMACEUTICAL SOC JAPAN
WOS记录号	WOS:000440878700007
资助机构	One Hundred Person Project of the Chinese Academy of Sciences(Y229461211) ; Applied Basic Research Programs of Qinghai Province ; Science and Technology Plan Projects in Qinghai Province(2015-ZJ-733)
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/13782]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
通讯作者	Shang, Jing
作者单位	1.China Pharmaceut Univ, Sch Tradit Chinese Pharm, Nanjing 211198, Jiangsu, Peoples R China 2.China Pharmaceut Univ, Jiangsu Key Lab TCM Evaluat & Translat Res, Nanjing 211198, Jiangsu, Peoples R China 3.China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Key Lab Tibetan Med Res, Northwest Inst Plateau Biol, Xining 810008, Peoples R China 6.Chinese Acad Sci, Qinghai Key Lab Tibetan Med Pharmacol & Safety Ev, Northwest Inst Plateau Biol, Xining 810008, Peoples R China
推荐引用方式 GB/T 7714	Shang, Jing,Wu, Huali,Zou, Xiaoyan,et al. Effect of the Tibetan Medicine Zuotai on Degranulation and Inflammatory Mediator Release in RBL-2H3 Cells[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2018,66(8):818-821.
APA	Shang, Jing.,Wu, Huali.,Zou, Xiaoyan.,Chen, Haijuan.,He, Qiangqiang.,...&Xia, Zhenjiang.(2018).Effect of the Tibetan Medicine Zuotai on Degranulation and Inflammatory Mediator Release in RBL-2H3 Cells.CHEMICAL & PHARMACEUTICAL BULLETIN,66(8),818-821.
MLA	Shang, Jing,et al."Effect of the Tibetan Medicine Zuotai on Degranulation and Inflammatory Mediator Release in RBL-2H3 Cells".CHEMICAL & PHARMACEUTICAL BULLETIN 66.8(2018):818-821.