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	Functionalized gold nanoclusters identify highly reactive oxygen species in living organisms
	Xie, Yangzhouyun1,2,3; Xianyu, Yunlei1,2; Wang, Nuoxin1,2; Yan, Zhaoyang4; Liu, Yong1,2; Zhu, Kui4; Hatzakis, Nikos S.5; Jiang, Xingyu1,2,3
刊名	Advanced functional materials
	2018-04-05
卷号	28期号:14页码:7
关键词	Fluorescent imaging Gold nanoclusters Intracellular detection Reactive oxygen species
ISSN号	1616-301X
DOI	10.1002/adfm.201702026
通讯作者	Jiang, xingyu(xingyujiang@nanoctr.cn)
英文摘要	Surface engineering of nanomaterials allows fine tuning of their interactions with biological systems, and thus can benefit their applications in monitoring intracellular events. herein, the facile synthesis of ligand-functionalized gold nanoclusters (auncs) as intracellular probes targeting highly reactive oxygen species (hros, such as center dot oh, clo-, and onoo-) is demonstrated. selected ligands such as quaternary ammonium and oligopeptides are utilized to modulate the surface chemistry of auncs. it is shown that auncs decorated with the cell-penetrating oligoarginine peptide facilitate cellular uptake and intracellular imaging of hros in living cells and the zebrafish, with high stability and selectivity.
WOS关键词	METAL NANOCLUSTERS ; FLUORESCENT-PROBES ; LIVE CELLS ; HYDROGEN-PEROXIDE ; OPTICAL PROBE ; NANOPARTICLES ; IDENTIFICATION ; PEROXYNITRITE ; EMISSION ; RADICALS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000429410400032
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2178144
专题	高能物理研究所
通讯作者	Jiang, Xingyu
作者单位	1.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Sino Danish Ctr Educ & Res, Beijing 100190, Peoples R China 4.China Agr Univ, Beijing 100193, Peoples R China 5.Univ Copenhagen, Dept Chem, DK-2100 Copenhagen, Denmark
推荐引用方式 GB/T 7714	Xie, Yangzhouyun,Xianyu, Yunlei,Wang, Nuoxin,et al. Functionalized gold nanoclusters identify highly reactive oxygen species in living organisms[J]. Advanced functional materials,2018,28(14):7.
APA	Xie, Yangzhouyun.,Xianyu, Yunlei.,Wang, Nuoxin.,Yan, Zhaoyang.,Liu, Yong.,...&Jiang, Xingyu.(2018).Functionalized gold nanoclusters identify highly reactive oxygen species in living organisms.Advanced functional materials,28(14),7.
MLA	Xie, Yangzhouyun,et al."Functionalized gold nanoclusters identify highly reactive oxygen species in living organisms".Advanced functional materials 28.14(2018):7.

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