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	Analyte-triggered dna-probe release from a triplex molecular beacon for nanopore sensing
	Guo, Bingyuan1,2,3; Sheng, Yingying1; Zhou, Ke2; Liu, Quansheng2; Liu, Lei2; Wu, Hai-Chen1
刊名	Angewandte chemie-international edition
	2018-03-26
卷号	57期号:14页码:3602-3606
关键词	Antibodies Biomarkers Molecular beacon Nanopore sensors Quantitative determination
ISSN号	1433-7851
DOI	10.1002/anie.201711690
通讯作者	Liu, lei(leiliu@ihep.ac.cn) ; Wu, hai-chen(haichenwu@iccas.ac.cn)
英文摘要	A new nanopore sensing strategy based on triplex molecular beacon was developed for the detection of specific dna or multivalent proteins. the sensor is composed of a triplex-forming molecular beacon and a stem-forming dna component that is modified with a host-guest complex. upon target dna hybridizing with the molecular beacon loop or multivalent proteins binding to the recognition elements on the stem, the dna probe is released and produces highly characteristic current signals when translocated through -hemolysin. the frequency of current signatures can be used to quantify the concentrations of the target molecules. this sensing approach provides a simple, quick, and modular tool for the detection of specific macromolecules with high sensitivity and excellent selectivity. it may find useful applications in point-of-care diagnostics with a portable nanopore kit in the future.
WOS关键词	ALPHA-HEMOLYSIN NANOPORE ; CANCER-PATIENTS ; NUCLEIC-ACIDS ; SOLID-STATE ; SINGLE ; PROTEIN ; BIOMARKERS ; ANTIBODY ; DISCRIMINATION ; NANOSTRUCTURES
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000428350100008
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2178141
专题	高能物理研究所
通讯作者	Liu, Lei; Wu, Hai-Chen
作者单位	1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Multidisciplinary Ctr, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Guo, Bingyuan,Sheng, Yingying,Zhou, Ke,et al. Analyte-triggered dna-probe release from a triplex molecular beacon for nanopore sensing[J]. Angewandte chemie-international edition,2018,57(14):3602-3606.
APA	Guo, Bingyuan,Sheng, Yingying,Zhou, Ke,Liu, Quansheng,Liu, Lei,&Wu, Hai-Chen.(2018).Analyte-triggered dna-probe release from a triplex molecular beacon for nanopore sensing.Angewandte chemie-international edition,57(14),3602-3606.
MLA	Guo, Bingyuan,et al."Analyte-triggered dna-probe release from a triplex molecular beacon for nanopore sensing".Angewandte chemie-international edition 57.14(2018):3602-3606.

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