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	A dna nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo
	Li, Suping1,2; Jiang, Qiao1; Liu, Shaoli1,2; Zhang, Yinlong1,3; Tian, Yanhua1,4; Song, Chen1; Wang, Jing1; Zou, Yiguo1; Anderson, Gregory J.5; Han, Jing-Yan6
刊名	Nature biotechnology
	2018-03-01
卷号	36期号:3页码:258-+
ISSN号	1087-0156
DOI	10.1038/nbt.4071
通讯作者	Nie, guangjun(niegj@nanoctr.cn) ; Yan, hao(hao.yan@asu.edu) ; Ding, baoquan(dingbq@nanoctr.cn) ; Zhao, yuliang(zhaoyl@nanoctr.cn)
英文摘要	Nanoscale robots have potential as intelligent drug delivery systems that respond to molecular triggers(1-4). using dna origami we constructed an autonomous dna robot programmed to transport payloads and present them specifically in tumors. our nanorobot is functionalized on the outside with a dna aptamer that binds nucleolin, a protein specifically expressed on tumor-associated endothelial cells(5), and the blood coagulation protease thrombin within its inner cavity. the nucleolin-targeting aptamer serves both as a targeting domain and as a molecular trigger for the mechanical opening of the dna nanorobot. the thrombin inside is thus exposed and activates coagulation at the tumor site. using tumor-bearing mouse models, we demonstrate that intravenously injected dna nanorobots deliver thrombin specifically to tumor-associated blood vessels and induce intravascular thrombosis, resulting in tumor necrosis and inhibition of tumor growth. the nanorobot proved safe and immunologically inert in mice and bama miniature pigs. our data show that dna nanorobots represent a promising strategy for precise drug delivery in cancer therapy.
WOS关键词	TUMOR VASCULATURE ; DRUG-DELIVERY ; TISSUE FACTOR ; ORIGAMI ; NUCLEOLIN ; CELL ; NANOTECHNOLOGY ; THROMBOSIS ; NANOSCALE ; PROTEINS
WOS研究方向	Biotechnology & Applied Microbiology
WOS类目	Biotechnology & Applied Microbiology
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000426698700021
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2178140
专题	高能物理研究所
通讯作者	Nie, Guangjun; Yan, Hao; Ding, Baoquan; Zhao, Yuliang
作者单位	1.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Nanosyst & Hierarch Fabricat, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Jilin Univ, Coll Pharmaceut Sci, Changchun, Jilin, Peoples R China 4.Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China 5.QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia 6.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing, Peoples R China 7.Arizona State Univ, Ctr Mol Design & Biomimet, Sch Mol Sci, Tempe, AZ USA 8.Arizona State Univ, Sch Life Sci, Ctr Immunotherapy Vaccines & Virotherapy, Biodesign Inst, Tempe, AZ USA 9.Chinese Acad Sci, Inst Zool, Beijing, Peoples R China 10.Jinan Univ, Coll Life Sci & Technol, Inst Life & Hlth Engn, Guangzhou, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Li, Suping,Jiang, Qiao,Liu, Shaoli,et al. A dna nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo[J]. Nature biotechnology,2018,36(3):258-+.
APA	Li, Suping.,Jiang, Qiao.,Liu, Shaoli.,Zhang, Yinlong.,Tian, Yanhua.,...&Zhao, Yuliang.(2018).A dna nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo.Nature biotechnology,36(3),258-+.
MLA	Li, Suping,et al."A dna nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo".Nature biotechnology 36.3(2018):258-+.

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