| Reverse reconstruction and bioprinting of bacterial cellulose-based functional total intervertebral disc for therapeutic implantation | |
| Yang, Junchuan1,2; Wang, Le2; Zhang, Wei3; Sun, Zhen1; Li, Ying1,2; Yang, Mingzhu2; Zeng, Di1; Peng, Baogan3; Zheng, Wenfu2; Jiang, Xingyu2,4 | |
| 刊名 | Small
 |
| 2018-02-15 | |
| 卷号 | 14期号:7页码:9 |
| 关键词 | Bacterial cellulose Bioprint Intervertebral disc Micropattern Tissue engineering |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201702582 |
| 通讯作者 | Zheng, wenfu(zhengwf@nanoctr.cn) ; Jiang, xingyu(xingyujiang@nanoctr.cn) ; Yang, guang(yang_sunny@yahoo.com) |
| 英文摘要 | The degradation of intervertebral discs (ivd), a typical hierarchical structured tissue, causes serious neck and back pain. the current methods cannot fully reconstitute the unique structure and function of native ivd. in this study, by reverse reconstruction of the structure of native ivd and bioprinting bacterial cellulose (bc) nanofibers with a high-throughput optimized micropattern screening microchip, a total ivd is created that contained type ii collagen-based nucleus pulposus (np) and hierarchically organized and micropatterned bc-based annulus fibrosus (af), mimicking native ivd tissue. the artificial np contains rat np cells, whereas the af contains concentrically arranged bc layers with aligned micropatterns and attached af cells in +/-30 degrees alternate directions between adjacent layers. long-term (3 months) implantation experiments on rats demonstrate the excellent structural (shape maintenance, hydration, tissue integration) and functional (mechanical support and flexibility) performance of the artificial ivd. this study provides a novel strategy for creating highly sophisticated artificial tissues. |
| WOS关键词 | CELL-MIGRATION ; TISSUE ; FIBROSUS ; HYDROGEL ; STRATEGY |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000425147000014 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2178022 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zheng, Wenfu; Jiang, Xingyu; Yang, Guang |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Dept Biomed Engn, Natl Engn Res Ctr Nanomed, Wuhan 430074, Hubei, Peoples R China 2.Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing Engn Res Ctr BioNanotechnol, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 3.Gen Hosp Armed Police Force, Dept Spinal Surg, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Junchuan,Wang, Le,Zhang, Wei,et al. Reverse reconstruction and bioprinting of bacterial cellulose-based functional total intervertebral disc for therapeutic implantation[J]. Small,2018,14(7):9. |
| APA | Yang, Junchuan.,Wang, Le.,Zhang, Wei.,Sun, Zhen.,Li, Ying.,...&Yang, Guang.(2018).Reverse reconstruction and bioprinting of bacterial cellulose-based functional total intervertebral disc for therapeutic implantation.Small,14(7),9. |
| MLA | Yang, Junchuan,et al."Reverse reconstruction and bioprinting of bacterial cellulose-based functional total intervertebral disc for therapeutic implantation".Small 14.7(2018):9. |
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