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	Carrier-free, self-assembled pure drug nanorods composed of 10-hydroxycamptothecin and chlorin e6 for combinatorial chemo-photodynamic antitumor therapy in vivo
	Wen, Yan1,2,3; Zhang, Wei1,2; Gong, Ningqiang1,2,3; Wang, Yi-Feng1,2,3; Guo, Hong-Bo1,2; Guo, Weisheng1,2; Wang, Paul C.4,5; Liang, Xing-Jie1,2,3
刊名	Nanoscale
	2017-10-14
卷号	9期号:38页码:14347-14356
ISSN号	2040-3364
DOI	10.1039/c7nr03129g
通讯作者	Zhang, wei(zhangwei@nanoctr.cn) ; Liang, xing-jie(liangxj@nanoctr.cn)
英文摘要	Carrier-free nanodrugs formulated from the supramolecular self-assembly of pure drug molecules have emerged as an innovative and promising strategy for tumor therapy. we report herein a new and simple method to directly assemble a small hydrophobic anticancer drug, 10-hydroxycamptothecin (hcpt), with a photosensitizer chlorin e6 (ce6) to form stable, discrete nanorods (nrs), which not only circumvent the extreme hydrophobicity of hcpt but also incorporate two different modalities into one delivery system for combination therapy. different ratios of hcpt to ce6 were evaluated to afford the optimal nanoformulation. the as-prepared hcpt/ce6 nrs were fully characterized, indicating a relatively uniform size of about 360 nm in length and 135 nm in width, and a surface charge of about -33 mv. efficient internalization of the nrs by cancer cells was observed by using a confocal microscope and the generation of singlet oxygen species arising from the nrs under 655 nm laser irradiation was detected by dcfh-da. as a result, very potent in vitro efficacy against several kinds of cancer cell lines was achieved through chemo-photodynamic dual therapy. the in vivo tumor suppression effect of hcpt/ce6 nrs was verified on a subcutaneous xenograft mouse model, achieving almost complete inhibition of the tumor growth, which may benefit from the superiority of nanomedicine and combination therapy. the rationale of this facile and green strategy for carrier-free nanodrug formulation via the self-assembly approach might provide new opportunities for the development of combinatorial therapeutics for tumors.
WOS关键词	MESOPOROUS SILICA NANOPARTICLES ; CELL LUNG-CANCER ; CO-DELIVERY ; POLYMERIC NANOPARTICLES ; MULTIDRUG-RESISTANCE ; CONTROLLED-RELEASE ; TUMOR PENETRATION ; BREAST-CANCER ; DOXORUBICIN ; NANOMEDICINE
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000412407300007
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177785
专题	高能物理研究所
通讯作者	Zhang, Wei; Liang, Xing-Jie
作者单位	1.Chinese Acad Sci, Ctr Excellence Nanosci, Lab Controllable Nanopharmaceut, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Howard Univ, Dept Radiol, Lab Mol Imaging, Washington, DC 20060 USA 5.Fu Jen Catholic Univ, Coll Sci & Engn, Taipei 24205, Taiwan
推荐引用方式 GB/T 7714	Wen, Yan,Zhang, Wei,Gong, Ningqiang,et al. Carrier-free, self-assembled pure drug nanorods composed of 10-hydroxycamptothecin and chlorin e6 for combinatorial chemo-photodynamic antitumor therapy in vivo[J]. Nanoscale,2017,9(38):14347-14356.
APA	Wen, Yan.,Zhang, Wei.,Gong, Ningqiang.,Wang, Yi-Feng.,Guo, Hong-Bo.,...&Liang, Xing-Jie.(2017).Carrier-free, self-assembled pure drug nanorods composed of 10-hydroxycamptothecin and chlorin e6 for combinatorial chemo-photodynamic antitumor therapy in vivo.Nanoscale,9(38),14347-14356.
MLA	Wen, Yan,et al."Carrier-free, self-assembled pure drug nanorods composed of 10-hydroxycamptothecin and chlorin e6 for combinatorial chemo-photodynamic antitumor therapy in vivo".Nanoscale 9.38(2017):14347-14356.

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