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	Mussel inspired polynorepinephrine functionalized electrospun polycaprolactone microfibers for muscle regeneration
	Liu, Ying1,2; Zhou, Guoqiang4; Liu, Zhu1,2,4; Guo, Mengyu1,2; Jiang, Xiumei1,2; Taskin, Mehmet Berat3; Zhang, Zhongyang3; Liu, Jing1,2; Tang, Jinglong1,2; Bai, Ru1,2
刊名	Scientific reports
	2017-08-15
卷号	7页码:10
ISSN号	2045-2322
DOI	10.1038/s41598-017-08572-z
通讯作者	Chen, menglin(menglin@inano.au.dk) ; Chen, chunying(chenchy@nanoctr.cn)
英文摘要	Electrospun scaffolds with excellent mechanical properties, high specific surface area and a commendable porous network are widely used in tissue engineering. improving the hydrophilicity and cell adhesion of hydrophobic substrates is the key point to enhance the effectiveness of electrospun scaffolds. in this study, polycaprolactone (pcl) fibrous membranes with appropriate diameter were selected and coated by mussel-inspired poly norepinephrine (pne). and norepinephrine is a catecholamine functioning as a hormone and neurotransmitter in the human brain. the membrane with smaller diameter fibers, a relative larger specific surface area and the suitable pne functionalization provided more suitable microenvironment for cell adhesion and proliferation both in vitro and in vivo. the regenerated muscle layer can be integrated well with fibrous membranes and surrounding tissues at the impaired site and thus the mechanical strength reached the value of native tissue. the underlying molecular mechanism is mediated via inhibiting myostatin expression by pi3k/akt/mtor hypertrophy pathway. the properly functionalized fibrous membranes hold the potential for repairing muscle injuries. our current work also provides an insight for rational design and development of better tissue engineering materials for skeletal muscle regeneration.
WOS关键词	TISSUE ENGINEERING APPLICATIONS ; SURFACE MODIFICATION ; ACID) SCAFFOLDS ; CELL ; CHEMISTRY ; POLY(NOREPINEPHRINE) ; FIBERS ; GROWTH
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000407570000074
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177784
专题	高能物理研究所
通讯作者	Chen, Menglin; Chen, Chunying
作者单位	1.Natl Ctr Nanosci & Technol China NCNST, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol China NCNST, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 3.Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, DK-8000 Aarhus C, Denmark 4.Hebei Univ, Coll Chem & Environm Sci, Minist Educ, Key Lab Med Chem & Mol Diag, Baoding 071002, Peoples R China
推荐引用方式 GB/T 7714	Liu, Ying,Zhou, Guoqiang,Liu, Zhu,et al. Mussel inspired polynorepinephrine functionalized electrospun polycaprolactone microfibers for muscle regeneration[J]. Scientific reports,2017,7:10.
APA	Liu, Ying.,Zhou, Guoqiang.,Liu, Zhu.,Guo, Mengyu.,Jiang, Xiumei.,...&Chen, Chunying.(2017).Mussel inspired polynorepinephrine functionalized electrospun polycaprolactone microfibers for muscle regeneration.Scientific reports,7,10.
MLA	Liu, Ying,et al."Mussel inspired polynorepinephrine functionalized electrospun polycaprolactone microfibers for muscle regeneration".Scientific reports 7(2017):10.

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