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	Ultrasmall gold nanoparticles behavior in vivo modulated by surface polyethylene glycol (peg) grafting
	Huo, Shuaidong1,2,3; Chen, Shizhu1,2,4; Gong, Ningqiang1,2,3; Liu, Juan1,2,5; Li, Xianlei1,2,3; Zhao, Yuanyuan1,2; Liang, Xing-Jie1,2,3,4
刊名	Bioconjugate chemistry
	2017
卷号	28期号:1页码:239-243
ISSN号	1043-1802
DOI	10.1021/acs.bioconjchem.6b00488
通讯作者	Huo, shuaidong(huosd@nanoctr.cn) ; Liang, xing-jie(liangxj@nanoctr.cn)
英文摘要	Ultrasmall nanoparticles provide us with essential alternatives for designing more efficient nanocarriers for drug delivery. however, the fast clearance of ultrasmall nanoparticles limits their application to some extent. one of the most frequently used compound to slow the clearance of nanocarriers and nanodrugs is peg, which is also approved by fda. nonetheless, few reports explored the effect of the pegylation of ultrasmall nanoparticles on their behavior in vivo. herein, we investigated the impact of different peg grafting level of 2 nm core sized gold nanoparticles on their biological behavior in tumor-bearing mice. the results indicate that partial (similar to 50%) surface pegylation could prolong the blood circulation and increase the tumor accumulation of ultrasmall nanoparticles to a maximum extent, which guide us to build more profitable small-sized nanocarriers for drug delivery.
WOS关键词	RENAL CLEARANCE ; DRUG-DELIVERY ; SIZE ; BIODISTRIBUTION ; PENETRATION ; PEGYLATION ; INJECTION ; MOLECULES ; THERAPY ; BINDING
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary ; Chemistry, Organic
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000392459200027
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177778
专题	高能物理研究所
通讯作者	Huo, Shuaidong; Liang, Xing-Jie
作者单位	1.Chinese Acad Sci, Lab Controllable Nanopharmaceut, Ctr Excellence Nanosci, 11 Beiyitiao, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Hebei Univ, Coll Chem & Environm Sci, Chem Biol Key Lab Hebei Prov, Baoding 071002, Peoples R China 5.Beijing Inst Transfus Med, Tissue Engn Lab, Beijing 100850, Peoples R China
推荐引用方式 GB/T 7714	Huo, Shuaidong,Chen, Shizhu,Gong, Ningqiang,et al. Ultrasmall gold nanoparticles behavior in vivo modulated by surface polyethylene glycol (peg) grafting[J]. Bioconjugate chemistry,2017,28(1):239-243.
APA	Huo, Shuaidong.,Chen, Shizhu.,Gong, Ningqiang.,Liu, Juan.,Li, Xianlei.,...&Liang, Xing-Jie.(2017).Ultrasmall gold nanoparticles behavior in vivo modulated by surface polyethylene glycol (peg) grafting.Bioconjugate chemistry,28(1),239-243.
MLA	Huo, Shuaidong,et al."Ultrasmall gold nanoparticles behavior in vivo modulated by surface polyethylene glycol (peg) grafting".Bioconjugate chemistry 28.1(2017):239-243.

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