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	A self-destructive nanosweeper that captures and clears amyloid beta-peptides
	Luo, Qiang1,2; Lin, Yao-Xin2,3,4; Yang, Pei-Pei2; Wang, Yi2,3; Qi, Guo-Bin2; Qiao, Zeng-Ying2; Li, Bing-Nan1,2; Zhang, Kuo1,2; Zhang, Jing-Ping1; Wang, Lei2
刊名	Nature communications
	2018-05-04
卷号	9页码:12
ISSN号	2041-1723
DOI	10.1038/s41467-018-04255-z
通讯作者	Zhang, jing-ping(zhangjp162@nenu.edu.cn) ; Wang, lei(wanglei@nanoctr.cn) ; Wang, hao(wanghao@nanoctr.cn)
英文摘要	Cerebral amyloid beta-peptide (a beta) accumulation resulting from an imbalance between a beta production and clearance is one of the most important causes in the formation of alzheimer's disease (ad). in order to preserve the maintenance of a beta homeostasis and have a notable ad therapy, achieving a method to clear up a beta plaques becomes an emerging task. herein, we describe a self-destructive nanosweeper based on multifunctional peptide-polymers that is capable of capturing and clearing a beta for the effective treatment of ad. the nanosweeper recognize and bind a beta via co-assembly through hydrogen bonding interactions. the a beta-loaded nanosweeper enters cells and upregulates autophagy thus promoting the degradation of a beta. as a result, the nanosweeper decreases the cytotoxicity of a beta and rescues memory deficits of ad transgenic mice. we believe that this resourceful and synergistic approach has valuable potential as an ad treatment strategy.
WOS关键词	BLOOD-BRAIN-BARRIER ; ALZHEIMERS-DISEASE ; IN-VIVO ; MONITORING AUTOPHAGY ; TRANSGENIC MICE ; AGGREGATION ; NANOPARTICLES ; THERAPY ; FIBRILLOGENESIS ; CYTOTOXICITY
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000431407800007
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177613
专题	高能物理研究所
通讯作者	Zhang, Jing-Ping; Wang, Lei; Wang, Hao
作者单位	1.Northeast Normal Univ, Fac Chem, Changchun 130024, Jilin, Peoples R China 2.Natl Ctr Nanosci & Technol NCNST, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Guangzhou 510006, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Luo, Qiang,Lin, Yao-Xin,Yang, Pei-Pei,et al. A self-destructive nanosweeper that captures and clears amyloid beta-peptides[J]. Nature communications,2018,9:12.
APA	Luo, Qiang.,Lin, Yao-Xin.,Yang, Pei-Pei.,Wang, Yi.,Qi, Guo-Bin.,...&Wang, Hao.(2018).A self-destructive nanosweeper that captures and clears amyloid beta-peptides.Nature communications,9,12.
MLA	Luo, Qiang,et al."A self-destructive nanosweeper that captures and clears amyloid beta-peptides".Nature communications 9(2018):12.

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