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	Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects
	Liu, Yi1,2; Li, Heping1; Xie, Jin2; Zhou, Mengxue2,3; Huang, Hui2,3; Lu, Huiru2; Chai, Zhifang2; Chen, Jun2; Hu, Yi2
刊名	Biomaterials science
	2017-05-01
卷号	5期号:5页码:1022-1031
ISSN号	2047-4830
DOI	10.1039/c6bm00878j
通讯作者	Li, heping(lihp@csust.edu.cn) ; Chen, jun(chenjun@ihep.ac.cn) ; Hu, yi(huyi@ihep.ac.cn)
英文摘要	Phototherapy, as a noninvasive therapeutic procedure, has been applied to treat tumors. however, the application of phototherapy is often compromised by its low efficiency. herein, we developed a novel nanoplatform based on cationic amphiphilic polymer-wrapped carbon nanotubes (rpaa@swcnts) with a photosensitizer, indocyanine green (icg), for phototherapy. the as-prepared nanoparticles exhibited excellent mitochondria targeting due to the synergistic properties of highly positive charges from the polycations on the corona and the high hydrophobicity from the carbon nanotubes in the core. moreover, the high buffer capacity of the polycations facilitated the endosomal escape of nanoparticles via a proton-sponge effect. when irradiated with an 808 nm nir laser, icg/rpaa@swcnts could precisely damage mitochondria with high efficiency and produce reactive oxygen species (ros) and hyperthermia, which further induced the ros burst from damaged mitochondria. the overproduced ros accumulated in mitochondria ultimately resulted in mitochondrial damage and cell death. therefore icg/rpaa@ swcnts may be able to achieve an amplifying phototherapeutic effect.
WOS关键词	WALLED CARBON NANOTUBES ; PHOTODYNAMIC THERAPY ; CANCER-THERAPY ; DRUG-DELIVERY ; IN-VIVO ; PHOTOTHERMAL THERAPY ; CO-DELIVERY ; LIGHT ; CHEMOTHERAPY ; PHOTOSENSITIZER
WOS研究方向	Materials Science
WOS类目	Materials Science, Biomaterials
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000400690700012
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177189
专题	高能物理研究所
通讯作者	Li, Heping; Chen, Jun; Hu, Yi
作者单位	1.Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Key Lab Rd Struct & Mat, Minist Transport, Changsha 410114, Hunan, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Multidisciplinary Res Div, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yi,Li, Heping,Xie, Jin,et al. Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects[J]. Biomaterials science,2017,5(5):1022-1031.
APA	Liu, Yi.,Li, Heping.,Xie, Jin.,Zhou, Mengxue.,Huang, Hui.,...&Hu, Yi.(2017).Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects.Biomaterials science,5(5),1022-1031.
MLA	Liu, Yi,et al."Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects".Biomaterials science 5.5(2017):1022-1031.

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