| An "on-site transformation" strategy for treatment of bacterial infection | |
| Qi, Guo-Bin; Zhang, Di; Liu, Fu-Hua; Qiao, Zeng-Ying; Wang, Hao | |
| 刊名 | Advanced materials
 |
| 2017-09-27 | |
| 卷号 | 29期号:36页码:10 |
| 关键词 | Bacterial infection Chitosan Enzyme-cleavable Peptides Transformation |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.201703461 |
| 通讯作者 | Qiao, zeng-ying(qiaozy@nanoctr.cn) ; Wang, hao(wanghao@nanoctr.cn) |
| 英文摘要 | To date, numerous nanosystems have been developed as antibiotic replacements for bacterial infection treatment. however, these advanced systems are limited owing to their nontargeting accumulation and the consequent side effects. herein, transformable polymer-peptide biomaterials have been developed that enable specific accumulation in the infectious site and long-term retention, resulting in enhanced binding capability and killing efficacy toward bacteria. the polymer-peptide conjugates are composed of a chitosan backbone and two functional peptides, i.e., an antimicrobial peptide and a poly(ethylene glycol)-tethered enzyme-cleavable peptide (cpc-1). the cpc-1 initially self-assembles into nanoparticles with pegylated coronas. upon the peptides are cleaved by the gelatinase secreted by a broad spectrum of bacterial species, the resultant compartments of nanoparticles spontaneously transformed into fibrous nanostructures that are stabilized by enhanced chain-chain interaction, leading to exposure of antimicrobial peptide residues for multivalent cooperative electrostatic interactions with bacterial membranes. intriguingly, the in situ morphological transformation also critically improves the accumulation and retention of cpc-1 in infectious sites in vivo, which exhibits highly efficient antibacterial activity. this proof-of-concept study demonstrates that pathological environment-driven smart self-assemblies may provide a new idea for design of high-performance biomaterials for disease diagnostics and therapeutics. |
| WOS关键词 | ANTIMICROBIAL PEPTIDES ; ANTIBACTERIAL PEPTIDES ; SELECTIVE RECOGNITION ; ANTIBIOTIC-RESISTANCE ; MOLECULAR-MECHANISMS ; MAMMALIAN-CELLS ; HILL EQUATION ; NANOPARTICLES ; PARTICLES ; CHITOSAN |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000411379000030 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2177097 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Qiao, Zeng-Ying; Wang, Hao |
| 作者单位 | Natl Ctr Nanosci & Technol NCNST, CAS Ctr Excellence Nanosci, Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, Guo-Bin,Zhang, Di,Liu, Fu-Hua,et al. An "on-site transformation" strategy for treatment of bacterial infection[J]. Advanced materials,2017,29(36):10. |
| APA | Qi, Guo-Bin,Zhang, Di,Liu, Fu-Hua,Qiao, Zeng-Ying,&Wang, Hao.(2017).An "on-site transformation" strategy for treatment of bacterial infection.Advanced materials,29(36),10. |
| MLA | Qi, Guo-Bin,et al."An "on-site transformation" strategy for treatment of bacterial infection".Advanced materials 29.36(2017):10. |
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