| Enhanced radiotherapy using bismuth sulfide nanoagents combined with photo-thermal treatment | |
| Cheng, Xiaju1; Yong, Yuan3,4; Dai, Yiheng2; Song, Xin1; Yang, Gang1; Pan, Yue2; Ge, Cuicui1 | |
| 刊名 | Theranostics
 |
| 2017 | |
| 卷号 | 7期号:17页码:4087-4098 |
| 关键词 | Multimodal imaging Radiation therapy Hypoxia Dna repair Synergistic therapy |
| ISSN号 | 1838-7640 |
| DOI | 10.7150/thno.20548 |
| 通讯作者 | Pan, yue(panyue@suda.edu.cn) ; Ge, cuicui(ccge@suda.edu.cn) |
| 英文摘要 | Nanotechniques that can improve the effectiveness of radiotherapy (rt) by integrating it with multimodal imaging are highly desirable. results in this study, we fabricated bi2s3 nanorods that have attractive features such as their ability to function as contrast agents for x-ray computed tomography (ct) and photoacoustic (pa) imaging as well as good biocompatibility. both in vitro and in vivo studies confirmed that the bi2s3 nanoagents could potentiate the lethal effects of radiation via amplifying the local radiation dose and enhancing the anti-tumor efficacy of rt by augmenting the photo-thermal effect. furthermore, the nanoagent-mediated hyperthermia could effectively increase the oxygen concentration in hypoxic regions thereby inhibiting the expression of hypoxia-inducible factor (hif-1 alpha). this, in turn, interfered with dna repair via decreasing the expression of dna repair-related proteins to overcome radio-resistance. also, rt combined with nanoagent-mediated hyperthermia could substantially suppress tumor metastasis via down-regulating angiogenic factors. conclusion in summary, we constructed a single-component powerful nanoagent for ct/pa imaging-guided tumor radiotherapy and, most importantly, explored the potential mechanisms of nanoagent-mediated photo-thermal treatment for enhancing the efficacy of rt in a synergistic manner. |
| WOS关键词 | DOUBLE-STRAND BREAKS ; IONIZING-RADIATION ; SYNERGISTIC THERAPY ; POLY(ADP-RIBOSE) POLYMERASE-1 ; MILD HYPERTHERMIA ; TUMOR OXYGENATION ; DNA-DAMAGE ; CANCER ; NANOPARTICLES ; REPAIR |
| WOS研究方向 | Research & Experimental Medicine |
| WOS类目 | Medicine, Research & Experimental |
| 语种 | 英语 |
| 出版者 | IVYSPRING INT PUBL |
| WOS记录号 | WOS:000412296800002 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2177074 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Pan, Yue; Ge, Cuicui |
| 作者单位 | 1.Soochow Univ, Collaborat Innovat Ctr Radiat Med, Sch Radiol & Interdisciplinary Sci RAD X, Sch Radiat Med & Protect,Jiangsu Higher Educ Inst, Suzhou 215123, Peoples R China 2.Soochow Univ, State & Local Joint Engn Lab Novel Funct Polymer, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China 3.Southwest Minzu Univ, Coll Chem & Environm Protect Engn, Chengdu 610041, Sichuan, Peoples R China 4.Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, Xiaju,Yong, Yuan,Dai, Yiheng,et al. Enhanced radiotherapy using bismuth sulfide nanoagents combined with photo-thermal treatment[J]. Theranostics,2017,7(17):4087-4098. |
| APA | Cheng, Xiaju.,Yong, Yuan.,Dai, Yiheng.,Song, Xin.,Yang, Gang.,...&Ge, Cuicui.(2017).Enhanced radiotherapy using bismuth sulfide nanoagents combined with photo-thermal treatment.Theranostics,7(17),4087-4098. |
| MLA | Cheng, Xiaju,et al."Enhanced radiotherapy using bismuth sulfide nanoagents combined with photo-thermal treatment".Theranostics 7.17(2017):4087-4098. |
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