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	Fullerenol nanoparticles suppress rankl-induced osteoclastogenesis by inhibiting differentiation and maturation
	Geng, Huan1,2; Chang, Ya-Nan2; Bai, Xue2,3; Liu, Shuitao1; Yuan, Qing2,3; Gu, Weihong2,3; Li, Juan2; Chen, Kui2; Xing, Gengyan1; Xing, Gengmei2
刊名	Nanoscale
	2017-09-14
卷号	9期号:34页码:12516-12523
ISSN号	2040-3364
DOI	10.1039/c7nr04365a
通讯作者	Xing, gengyan() ; Xing, gengmei(xinggm@ihep.ac.cn)
英文摘要	Bone health requires regulation of homeostatic equilibrium between osteoblasts and osteoclasts. the over-activation of osteoclasts can disrupt bone metabolism, resulting in osteoporosis and other boneloss diseases. fullerenol, a polyhydroxy derivative of fullerene, exhibits excellent biocompatibility. here we show that fullerenol nanoparticles exert two functions: inhibition of osteoclastic differentiation and blockage of pre-osteoclast fusion to restructure osteoclast maturation and function. experimentally, the nanoparticles reduced pre-osteoclast migration and inhibited ruffled border formation to block their maturation. in addition, fullerenol dose-dependently restricted the differentiation of bone marrow macrophage cells (bmms) to form osteoclasts following treatment with macrophage colony-stimulating factor (m-csf) and receptor activator of nuclear factor (nf)-kappa b (rankl) to activate nf-kappa b and mitogen activating protein kinase (mapk) signaling pathways. it is possible that the very small size of fullerenol allows it to directly cross the cellular membrane to access the cytoplasm and regulate osteoclastogenesis from bmms. our results suggest that fullerenol could be used to treat bone-loss diseases such as osteoporosis.
WOS关键词	ACTIN ; BONE ; MECHANISMS ; FUSION ; ORGANIZATION ; ACTIVATION ; PRECURSORS ; MIGRATION ; PODOSOME ; DISEASE
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000409215300035
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177010
专题	高能物理研究所
通讯作者	Xing, Gengyan; Xing, Gengmei
作者单位	1.Gen Hosp Chinese Peoples Armed Police Forces, Dept Orthoped, Beijing 100039, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Geng, Huan,Chang, Ya-Nan,Bai, Xue,et al. Fullerenol nanoparticles suppress rankl-induced osteoclastogenesis by inhibiting differentiation and maturation[J]. Nanoscale,2017,9(34):12516-12523.
APA	Geng, Huan.,Chang, Ya-Nan.,Bai, Xue.,Liu, Shuitao.,Yuan, Qing.,...&Xing, Gengmei.(2017).Fullerenol nanoparticles suppress rankl-induced osteoclastogenesis by inhibiting differentiation and maturation.Nanoscale,9(34),12516-12523.
MLA	Geng, Huan,et al."Fullerenol nanoparticles suppress rankl-induced osteoclastogenesis by inhibiting differentiation and maturation".Nanoscale 9.34(2017):12516-12523.

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