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	Rapid and visual detection of heparin based on the disassembly of polyelectrolyte-induced pyrene excimers
	Qiao, Yadong1; Yao, Zhiyi2; Ge, Wenqi2; Zhang, Li1; Wu, Hai-Chen2
刊名	Organic & biomolecular chemistry
	2017-03-28
卷号	15期号:12页码:2569-2574
ISSN号	1477-0520
DOI	10.1039/c7ob00115k
通讯作者	Yao, zhiyi(yaozy@ihep.ac.cn) ; Zhang, li(lizhang9@zzu.edu.cn) ; Wu, hai-chen(haichenwu@ihep.ac.cn)
英文摘要	We have developed a ratiometric sensor based on polyelectrolyte- induced pyrene excimers for the rapid and visual detection of heparin in aqueous media. this sensor has a simple preparation method, fast response, low cost, and high sensitivity and selectivity. as a complementary strategy for the detection of heparin based on the formation of pyrene excimers, this approach could identify heparin specifically over chondroitin sulphate, which is the major interferent in most sensing systems for the detection of heparin. the detection limit of this approach can be as low as 0.14 mu m using fluorescence measurements. to the best of our knowledge, this is among the lowest lod for the detection of heparin reported in the literature. it enables the rapid and visual detection of heparin both in buffered solution and serum samples.
WOS关键词	ELECTROCHEMICAL SENSOR ; NANOPARTICLES ; PROTAMINE ; ASSAY
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000397948000013
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176689
专题	高能物理研究所
通讯作者	Yao, Zhiyi; Zhang, Li; Wu, Hai-Chen
作者单位	1.Zhengzhou Univ, Sch Mat Sci & Engn, Zhengzhou 450052, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Qiao, Yadong,Yao, Zhiyi,Ge, Wenqi,et al. Rapid and visual detection of heparin based on the disassembly of polyelectrolyte-induced pyrene excimers[J]. Organic & biomolecular chemistry,2017,15(12):2569-2574.
APA	Qiao, Yadong,Yao, Zhiyi,Ge, Wenqi,Zhang, Li,&Wu, Hai-Chen.(2017).Rapid and visual detection of heparin based on the disassembly of polyelectrolyte-induced pyrene excimers.Organic & biomolecular chemistry,15(12),2569-2574.
MLA	Qiao, Yadong,et al."Rapid and visual detection of heparin based on the disassembly of polyelectrolyte-induced pyrene excimers".Organic & biomolecular chemistry 15.12(2017):2569-2574.

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