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	Co-delivery of doxorubicin and quercetin via mpeg-plga copolymer assembly for synergistic anti-tumor efficacy and reducing cardio-toxicity
	Qureshi, Waseem Akhtar1; Zhao, Ruifang1; Wang, Hai2; Ji, Tianjiao1; Ding, Yanping1; Ihsan, Ayesha3; Mujeeb, Ayeesha1; Nie, Guangjun1; Zhao, Yuliang1
刊名	Science bulletin
	2016-11-01
卷号	61期号:21页码:1689-1698
关键词	Polymeric nanoparticles Doxorubicin Quercetin Cardio-toxicity Cancer therapy
ISSN号	2095-9273
DOI	10.1007/s11434-016-1182-z
通讯作者	Nie, guangjun(niegj@nanoctr.cn) ; Zhao, yuliang(zhaoyl@nanoctr.cn)
英文摘要	Quercetin (que) is a natural multifunctional bioflavonoid, and has shown great potential for reducing adverse side effects and enhancing anti-tumor efficacy of chemotherapeutic drugs. however, its clinical application is limited due to very low solubility and structural instability in physiological systems. herein, we co-delivered hydrophobic quercetin and hydrophilic doxorubicin (dox) by developing a biocompatible nanocarrier comprising of an amphiphilic polymer, methoxy poly(ethylene glycol) and poly(d, l-lactide-co-glycolide), respectively. the anti-tumor and prophylactic efficacy of this system was evaluated in cellular and animal models. our findings illustrated that the dox-que nanoparticulate formulation protected normal vascular endothelial cells from either free or nanoparticulate doxorubicin-induced cytotoxicity and increased cancer cell death. compared with free doxorubicin and its nanoformulation, co-delivery of quercetin and doxorubicin using our nanosystem synergistically inhibited tumor growth, while maintaining normal levels of cardiac function indicators in serum and recovering the histopathological damages in heart tissue. this study demonstrates a promising strategy for enhancing anti-cancer drug efficacy and reducing nanoparticulate chemotherapy-induced toxicity on normal tissues.
WOS关键词	ENDOTHELIAL-CELLS ; POLYMERIC NANOPARTICLES ; HEART-FAILURE ; CARDIOTOXICITY ; APOPTOSIS ; ADRIAMYCIN ; MECHANISMS ; FLAVONOIDS ; METABOLITES ; INHIBITION
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	SCIENCE PRESS
WOS记录号	WOS:000387414100010
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176634
专题	高能物理研究所
通讯作者	Nie, Guangjun; Zhao, Yuliang
作者单位	1.Natl Ctr Nanosci & Technol, Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Ohio State Univ, Dept Biomed Engn, Columbus, OH 43210 USA 3.NIBGE, POB 577, Faisalabad, Pakistan
推荐引用方式 GB/T 7714	Qureshi, Waseem Akhtar,Zhao, Ruifang,Wang, Hai,et al. Co-delivery of doxorubicin and quercetin via mpeg-plga copolymer assembly for synergistic anti-tumor efficacy and reducing cardio-toxicity[J]. Science bulletin,2016,61(21):1689-1698.
APA	Qureshi, Waseem Akhtar.,Zhao, Ruifang.,Wang, Hai.,Ji, Tianjiao.,Ding, Yanping.,...&Zhao, Yuliang.(2016).Co-delivery of doxorubicin and quercetin via mpeg-plga copolymer assembly for synergistic anti-tumor efficacy and reducing cardio-toxicity.Science bulletin,61(21),1689-1698.
MLA	Qureshi, Waseem Akhtar,et al."Co-delivery of doxorubicin and quercetin via mpeg-plga copolymer assembly for synergistic anti-tumor efficacy and reducing cardio-toxicity".Science bulletin 61.21(2016):1689-1698.

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