| Multifunctional thermoresponsive designer peptide hydrogels | |
| De Leon-Rodriguez, Luis M.1; Hemar, Yacine2; Mo, Guang3; Mitra, Alok K.1; Cornish, Jillian4; Brimble, Margaret A.1,2 | |
| 刊名 | Acta biomaterialia
 |
| 2017 | |
| 卷号 | 47页码:40-49 |
| 关键词 | Peptide Hydrogel Thermoresponsive Adhesion Enzymatic-cleavage Mechanical characterization |
| ISSN号 | 1742-7061 |
| DOI | 10.1016/j.actbio.2016.10.014 |
| 通讯作者 | De leon-rodriguez, luis m.(l.deleon@auckland.ac.nz) ; Brimble, margaret a.(m.brim-ble@auckland.ac.nz) |
| 英文摘要 | We report the synthesis and characterization of multifunctional peptides comprised of a hydrogel forming beta-sheet peptide segment and a matrix metalloproteinase 2 substrate containing a propargylglycinyl linker that is further derivatized with an rgd peptide sequence via "click" chemistry. in contrast to currently known systems, these multifunctional peptides formed gels that are stiffer than those formed by their respective precursors. all the peptides showed reversible thermoresponsive properties, which render them as suitable lead systems for a variety of possible biomedical applications. statement of significance in general, it has been frequently observed that chemical biofunctionalization of peptide hydrogels adversely affects peptide assembly, hydrogel formation or mechanical properties, which severely compromises their application. a functionalization protocol that allows to generate peptide hydrogels that display significantly improved mechanical properties over their unfunctionalized counterparts is reported in this work. these peptides also showed thermoresponsive viscoelastic characteristics, including an example of a peptide hydrogel that displays lower critical solution temperature behaviour. (c) 2016 acta materialia inc. published by elsevier ltd. all rights reserved. |
| WOS关键词 | SELF-ASSEMBLING BIOMATERIALS ; MESENCHYMAL STEM-CELLS ; BETA-SHEET PEPTIDES ; RATIONAL DESIGN ; POLYPEPTIDE ; MATRICES ; SCAFFOLDS ; THERMOGEL ; SYSTEMS |
| WOS研究方向 | Engineering ; Materials Science |
| WOS类目 | Engineering, Biomedical ; Materials Science, Biomaterials |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000389102600004 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2176624 |
| 专题 | 高能物理研究所 |
| 通讯作者 | De Leon-Rodriguez, Luis M.; Brimble, Margaret A. |
| 作者单位 | 1.Univ Auckland, Sch Biol Sci, 3A Symonds St,Thomas Bldg, Auckland 1010, New Zealand 2.Univ Auckland, Sch Chem Sci, 23 Symonds St, Auckland 1010, New Zealand 3.Chinese Acad Sci, Inst High Energy Phys, Beijing Synchrotron Radiat Facil, Beijing, Peoples R China 4.Univ Auckland, Dept Med, Auckland, New Zealand |
| 推荐引用方式 GB/T 7714 | De Leon-Rodriguez, Luis M.,Hemar, Yacine,Mo, Guang,et al. Multifunctional thermoresponsive designer peptide hydrogels[J]. Acta biomaterialia,2017,47:40-49. |
| APA | De Leon-Rodriguez, Luis M.,Hemar, Yacine,Mo, Guang,Mitra, Alok K.,Cornish, Jillian,&Brimble, Margaret A..(2017).Multifunctional thermoresponsive designer peptide hydrogels.Acta biomaterialia,47,40-49. |
| MLA | De Leon-Rodriguez, Luis M.,et al."Multifunctional thermoresponsive designer peptide hydrogels".Acta biomaterialia 47(2017):40-49. |
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