| Precision combination therapy for triple negative breast cancer via biomimetic polydopamine polymer core-shell nanostructures | |
| Ding, Yanping1,2; Su, Shishuai1,2; Zhang, Ruirui1; Shao, Leihou1,2; Zhang, Yinlong1,3; Wang, Bin1,2; Li, Yiye1,2; Chen, Long1,2; Yu, Qun4; Wu, Yan1 | |
| 刊名 | Biomaterials
 |
| 2017 | |
| 卷号 | 113页码:243-252 |
| 关键词 | Spatiotemporal-controlled drug release Thermo-responsive Photothermal therapy Chemotherapy Small interfering rna |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2016.10.053 |
| 通讯作者 | Wu, yan(wuy@nanoctr.cn) ; Nie, guangjun(niegj@nanoctr.cn) |
| 英文摘要 | Photothermal-based combination therapy using functional nanomaterials shows great promise in eradication of aggressive tumors and improvement of drug sensitivity. the therapeutic efficacy and adverse effects of drug combinations depend on the precise control of timely tumor-localized drug release. here a polymer-dopamine nanocomposite is designed for combination therapy, thermo-responsive drug release and prevention of uncontrolled drug leakage. the thermo-sensitive co-polymer poly (2-(2-methoxyethoxy) ethyl methacrylate-co-oligo (ethylene glycol) methacrylate)-co-2-(dimethylamino) ethyl methacrylate-b-poly (d, l-lactide-co-glycolide) is constructed into core-shell structured nanoparticles for co-encapsulation of two cytotoxic drugs and absorption of small interfering rnas against survivin. the drug-loaded nanoparticles are surface-coated with polydopamine which confers the nanoformulation with photothermal activity and protects drugs from burst release. under tumor-localized laser irradiation, polydopamine generates sufficient heat, resulting in nano particle collapse and instant drug release within the tumor. the combination strategy of photothermal, chemo-, and gene therapy leads to triple-negative breast cancer regression, with a decrease in the. chemotherapeutic drug dosage to about 1/20 of conventional dose. this study establishes a powerful nanoplatform for precisely controlled combination therapy, with dramatic improvement of therapeutic efficacy and negligible side effects. (c) 2016 elsevier ltd. all rights reserved. |
| WOS关键词 | ENHANCED ANTITUMOR EFFICACY ; PHOTOTHERMAL THERAPY ; IN-VITRO ; SURFACE MODIFICATION ; NANOPARTICLES ; DELIVERY ; CHEMOTHERAPY ; DOXORUBICIN ; ENCAPSULATION ; NANOCARRIERS |
| WOS研究方向 | Engineering ; Materials Science |
| WOS类目 | Engineering, Biomedical ; Materials Science, Biomaterials |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000389396300020 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2176619 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wu, Yan; Nie, Guangjun |
| 作者单位 | 1.Natl Ctr Nanosci & Technol NCNST, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Jilin Univ, Coll Pharmaceut Sci, Changchun 130021, Peoples R China 4.Beijing Inst Transfus Med, Dept Immunohematol, 27 Taiping Rd, Beijing 100850, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, Yanping,Su, Shishuai,Zhang, Ruirui,et al. Precision combination therapy for triple negative breast cancer via biomimetic polydopamine polymer core-shell nanostructures[J]. Biomaterials,2017,113:243-252. |
| APA | Ding, Yanping.,Su, Shishuai.,Zhang, Ruirui.,Shao, Leihou.,Zhang, Yinlong.,...&Nie, Guangjun.(2017).Precision combination therapy for triple negative breast cancer via biomimetic polydopamine polymer core-shell nanostructures.Biomaterials,113,243-252. |
| MLA | Ding, Yanping,et al."Precision combination therapy for triple negative breast cancer via biomimetic polydopamine polymer core-shell nanostructures".Biomaterials 113(2017):243-252. |
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