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	Nanocrystalline cellulose improves the biocompatibility and reduces the wear debris of ultrahigh molecular weight polyethylene via weak binding
	Wang, Shiwen1,2,3; Feng, Qiang1,2; Sun, Jiashu1,2; Gao, Feng1,2; Fan, Wei1,2; Zhang, Zhong1,2; Li, Xiaohong3; Jiang, Xingyu1,2
刊名	Acs nano
	2016
卷号	10期号:1页码:298-306
关键词	Artificial joint Nanocrystalline cellulose Ultrahigh molecular weight polyethene Debris Friction
ISSN号	1936-0851
DOI	10.1021/acsnano.5b04393
通讯作者	Sun, jiashu(sunjs@nanoctr.cn) ; Li, xiaohong(xhli@swjtu.edu.cn) ; Jiang, xingyu(xingyujiang@nanoctr.cn)
英文摘要	The doping of biocompatible nanomaterials into ultrahigh molecular weight polyethylene (uhmwpe) to improve the biocompatibility and reduce the wear debris is of great significance to prolonging implantation time of uhmwpe as the bearing material for artificial joints. this study shows that uhmwpe can form a composite with nanocrystalline cellulose (ncc, a hydrophilic nanosized material with a high aspect ratio) by ball-milling and hot-pressing. compared to pure uhmwpe, the ncc/uhmwpe composite exhibits improved tribological characteristics with reduced generation of wear debris. the underlying mechanism is related to the weak binding between hydrophilic ncc and hydrophobic uhmwpe. the hydrophilic, rigid ncc particles tend to detach from the uhmwpe surface during friction, which could move with the rubbing surface, serve as a thin lubricant layer, and protect the uhmwpe substrate from abrasion. the biological safety of the ncc/uhmwpe composite, as tested by mc3t3-e1 preosteoblast cells and macrophage raw264.7 cells, is high, with significantly lower inflammatory responses/cytotoxicity than pure uhmwpe. the ncc/uhmwpe composite therefore could be a promising alternative to the current uhmwpe for bearing applications.
WOS关键词	CARBON NANOTUBES ; IN-VITRO ; SIZE ; NANOCOMPOSITES ; NANOPARTICLES ; BIOMATERIALS ; PARTICLES ; MECHANISM ; NANOPAPER ; FUTURE
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000369115800030
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176568
专题	高能物理研究所
通讯作者	Sun, Jiashu; Li, Xiaohong; Jiang, Xingyu
作者单位	1.Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, 11 Beiyitiao, Beijing 100190, Peoples R China 2.Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China 3.Southwest Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ China, Sch Mat Sci & Engn, Chengdu 610031, Peoples R China
推荐引用方式 GB/T 7714	Wang, Shiwen,Feng, Qiang,Sun, Jiashu,et al. Nanocrystalline cellulose improves the biocompatibility and reduces the wear debris of ultrahigh molecular weight polyethylene via weak binding[J]. Acs nano,2016,10(1):298-306.
APA	Wang, Shiwen.,Feng, Qiang.,Sun, Jiashu.,Gao, Feng.,Fan, Wei.,...&Jiang, Xingyu.(2016).Nanocrystalline cellulose improves the biocompatibility and reduces the wear debris of ultrahigh molecular weight polyethylene via weak binding.Acs nano,10(1),298-306.
MLA	Wang, Shiwen,et al."Nanocrystalline cellulose improves the biocompatibility and reduces the wear debris of ultrahigh molecular weight polyethylene via weak binding".Acs nano 10.1(2016):298-306.

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