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	Quercetin-loaded nanomicelles to circumvent human castration-resistant prostate cancer in vitro and in vivo
	Zhao, Jing1,2,3,4; Liu, Juan2,3; Wei, Tuo2,3; Ma, Xiaowei2,3; Cheng, Qiang5; Huo, Shuaidong2,3; Zhang, Chunqiu2,3; Zhang, Yanan4; Duan, Xianglin1; Liang, Xing-Jie2,3
刊名	Nanoscale
	2016
卷号	8期号:9页码:5126-5138
ISSN号	2040-3364
DOI	10.1039/c5nr08966b
通讯作者	Duan, xianglin(xlduan0311@163.com) ; Liang, xing-jie(liangxj@nanoctr.cn)
英文摘要	Prostate cancer is highly prevalent and has become the second leading cause of cancer-related death in men. its treatment remains a challenge in the clinic, particularly in patients who have advanced to "castration-resistant prostate cancer" (crpc). thus, more effective therapeutic strategies are required. quercetin (qct) is a natural flavonoid compound that has attracted increasing interest due to its anticancer activity. however, the clinical application of quercetin is largely hampered by its poor water solubility and low bioavailability. the objective of this study was to evaluate the therapeutic potential of novel qct-loaded nanomicelles (m-qcts) assembled from dspe-peg(2000) for prostate cancer treatment. our results indicated that qct was efficiently encapsulated into micelles up to 1 mg ml(-1), which corresponds to a 450-fold increase of its water solubility. in vitro studies showed that the half-maximal inhibitory concentration (ic50) value (20.2 mu m) of m-qcts was much lower than free qct (>200 mu m). thus, m-qcts were considerably more effective than free qct in proliferation inhibition and apoptosis induction of human androgen-independent pc-3 cells. furthermore, m-qcts showed superior antitumor efficacy and the tumor proliferation rate reduced by 52.03% compared to the control group in the pc-3 xenograft mouse model, possibly due to increased accumulation of m-qcts at the tumor site by the enhanced permeability and retention (epr) effect. collectively, our studies demonstrated that m-qcts significantly increase drug accumulation at the tumor site and exhibit superior anticancer activity in prostate cancer. thus, our nanomicelle-based drug delivery system constitutes a promising and effective therapeutic strategy for clinical treatment.
WOS关键词	DRUG-DELIVERY ; ANTIOXIDANT ACTIVITY ; PLA NANOPARTICLES ; MICELLES ; DOCETAXEL ; THERAPY ; CELLS ; PHARMACOKINETICS ; DOXORUBICIN ; PLATFORM
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000371479000038
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176548
专题	高能物理研究所
通讯作者	Duan, Xianglin; Liang, Xing-Jie
作者单位	1.Hebei Normal Univ, Coll Life Sci, Lab Mol Iron Metab, Shijiazhuang 050016, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, 11 First North Rd, Beijing 100190, Peoples R China 3.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, 11 First North Rd, Beijing 100190, Peoples R China 4.Hebei Med Univ, Dept Histol & Embryol, Shijiazhuang 050017, Peoples R China 5.Peking Univ, Inst Mol Med, Lab Nucle Acid Technol, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Jing,Liu, Juan,Wei, Tuo,et al. Quercetin-loaded nanomicelles to circumvent human castration-resistant prostate cancer in vitro and in vivo[J]. Nanoscale,2016,8(9):5126-5138.
APA	Zhao, Jing.,Liu, Juan.,Wei, Tuo.,Ma, Xiaowei.,Cheng, Qiang.,...&Liang, Xing-Jie.(2016).Quercetin-loaded nanomicelles to circumvent human castration-resistant prostate cancer in vitro and in vivo.Nanoscale,8(9),5126-5138.
MLA	Zhao, Jing,et al."Quercetin-loaded nanomicelles to circumvent human castration-resistant prostate cancer in vitro and in vivo".Nanoscale 8.9(2016):5126-5138.

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