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	Aspect ratios of gold nanoshell capsules mediated melanoma ablation by synergistic photothermal therapy and chemotherapy
	Wang, Hai1; Zhao, Ruifang1,2; Li, Yiye1; Liu, Huiyu3; Li, Feng1; Zhao, Yuliang1; Nie, Guangjun1
刊名	Nanomedicine-nanotechnology biology and medicine
	2016-02-01
卷号	12期号:2页码:439-448
关键词	Melanoma Gold nanoshell capsule Photothermal therapy Synergistic therapy Tumor imaging
ISSN号	1549-9634
DOI	10.1016/j.nano.2015.11.013
通讯作者	Li, yiye(liyy@nanoctr.cn) ; Nie, guangjun(niegj@nanoctr.cn)
英文摘要	Nanomaterial-mediated photothermal therapy has shown great potential to fulfill the unmet medical needs for treatment of tumors. in this study, a rod-like gold nanoshell capsule, which can offer both photothermal therapy and chemotherapy, is synthesized and applied for the treatment of melanoma. this nano-platform is made by developing a gold nanoshell on rod-like mesoporous silica nanoparticles with different aspect ratios, and it was found that the aspect ratio significantly influenced the cellular uptake and tumor distribution of the nanoparticles. the gold nanoshell capsules with a moderate aspect ratio are found to be efficiently taken up by melanoma cells and are able to penetrate tumor tissues, resulting in the effective ablation of highly malignant melanomas when used along with mild laser irradiation and a single treatment. this study demonstrates that the optimization of the aspect ratio is indispensable to further development of this nanoplatform for antitumor therapy. from the clinical editor: the combination of hyperthermia and chemotherapeutic agents has been investigated as a new approach for the treatment of malignant melanoma. it appears that the aspect ratio may play an important role in the treatment efficacy. in this article, the authors studied how the ar influenced the cellular uptake and the optimal ar for antitumor effects. (c) 2015 elsevier inc. all rights reserved.
WOS关键词	MESOPOROUS SILICA NANOPARTICLES ; POLYMER HYBRID NANOPARTICLES ; CELLULAR UPTAKE ; ANTITUMOR EFFICACY ; CANCER STATISTICS ; TUMOR-THERAPY ; DELIVERY ; MECHANISM ; CELLS
WOS研究方向	Science & Technology - Other Topics ; Research & Experimental Medicine
WOS类目	Nanoscience & Nanotechnology ; Medicine, Research & Experimental
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000373923400017
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176520
专题	高能物理研究所
通讯作者	Li, Yiye; Nie, Guangjun
作者单位	1.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing, Peoples R China 2.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China 3.Chinese Acad Sci, Tech Inst Phys & Chem, Lab Controllable Preparat & Applicat Nanomat, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wang, Hai,Zhao, Ruifang,Li, Yiye,et al. Aspect ratios of gold nanoshell capsules mediated melanoma ablation by synergistic photothermal therapy and chemotherapy[J]. Nanomedicine-nanotechnology biology and medicine,2016,12(2):439-448.
APA	Wang, Hai.,Zhao, Ruifang.,Li, Yiye.,Liu, Huiyu.,Li, Feng.,...&Nie, Guangjun.(2016).Aspect ratios of gold nanoshell capsules mediated melanoma ablation by synergistic photothermal therapy and chemotherapy.Nanomedicine-nanotechnology biology and medicine,12(2),439-448.
MLA	Wang, Hai,et al."Aspect ratios of gold nanoshell capsules mediated melanoma ablation by synergistic photothermal therapy and chemotherapy".Nanomedicine-nanotechnology biology and medicine 12.2(2016):439-448.

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