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	Smart micelle@polydopamine core-shell nanoparticles for highly effective chemo-photothermal combination therapy
	Zhang, Ruirui1; Su, Shishuai1; Hu, Kelei1,2; Shao, Leihou1; Deng, Xiongwei1,2; Sheng, Wang2; Wu, Yan1
刊名	Nanoscale
	2015
卷号	7期号:46页码:19722-19731
ISSN号	2040-3364
DOI	10.1039/c5nr04828a
通讯作者	Wu, yan(wuy@nanoctr.cn)
英文摘要	In this investigation, we have designed and synthesized a novel core-shell polymer nanoparticle system for highly effective chemo-photothermal combination therapy. a nanoscale dspe-peg micelle encapsulating doxorubicin (dox-m) was designed as a core, and then modified by a polydopamine (pda) shell for photothermal therapy and bortezomib (btz) administration (dox-m@pda-btz). the facile conjugation of btz to the catechol-containing pda shell can form a reversible ph-sensitive boronic acid-catechol conjugate to create a stimuli-responsive drug carrier system. as expected, the micelle@pda core-shell nanoparticles exhibited satisfactory photothermal efficiency, which has potential for thermal ablation of malignant tissues. in addition, on account of the pda modification, both dox and btz release processes were ph-dependent and nir-dependent. both in vitro and in vivo studies illustrated that the dox-m@pda-btz nanoparticles coupled with laser irradiation could enhance the cytotoxicity, and thus combinational therapy efficacy was achieved when integrating dox, btz, and pda into a single nanoplatform. altogether, our current study indicated that the micelle@polydopamine core-shell nanoparticles could be applied for nir/ph-responsive sustained-release and synergized chemo-photothermal therapy for breast cancer.
WOS关键词	MUSSEL-INSPIRED POLYDOPAMINE ; CANCER-THERAPY ; DRUG-DELIVERY ; GOLD NANORODS ; IN-VIVO ; SURFACE MODIFICATION ; CHEMOTHERAPY ; NANOCARRIERS ; DOXORUBICIN ; PACLITAXEL
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000365203000043
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176469
专题	高能物理研究所
通讯作者	Wu, Yan
作者单位	1.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ruirui,Su, Shishuai,Hu, Kelei,et al. Smart micelle@polydopamine core-shell nanoparticles for highly effective chemo-photothermal combination therapy[J]. Nanoscale,2015,7(46):19722-19731.
APA	Zhang, Ruirui.,Su, Shishuai.,Hu, Kelei.,Shao, Leihou.,Deng, Xiongwei.,...&Wu, Yan.(2015).Smart micelle@polydopamine core-shell nanoparticles for highly effective chemo-photothermal combination therapy.Nanoscale,7(46),19722-19731.
MLA	Zhang, Ruirui,et al."Smart micelle@polydopamine core-shell nanoparticles for highly effective chemo-photothermal combination therapy".Nanoscale 7.46(2015):19722-19731.

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