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	Multifunctional magnetic gd3+-based coordination polymer nanoparticles: combination of magnetic resonance and multispectral optoacoustic detections for tumor-targeted imaging in vivo
	An, Qiao1; Liu, Jing2; Yu, Meng1; Wan, Jiaxun1; Li, Dian1; Wang, Changchun1; Chen, Chunying2; Guo, Jia1
刊名	Small
	2015-11-11
卷号	11期号:42页码:5675-5686
ISSN号	1613-6810
DOI	10.1002/smll.201501491
通讯作者	Chen, chunying(chenchy@nanoctr.cn)
英文摘要	To overcome traditional barriers in optical imaging and microscopy, optoacoustic-imaging has been changed to combine the accuracy of spectroscopy with the depth resolution of ultrasound, achieving a novel modality with powerful in vivo imaging. however, magnetic resonance imaging provides better spatial and anatomical resolution. thus, a single hybrid nanoprobe that allows for simultaneous multimodal imaging is significant not only for cutting edge research in imaging science, but also for accurate clinical diagnosis. a core-shell-structured coordination polymer composite microsphere has been designed for in vivo multimodality imaging. it consists of a fe3o4 nanocluster core, a carbon sandwiched layer, and a carbocyanine-gd-iii (cy-gd-iii) coordination polymer outer shell (fe3o4@c@cy-gd-iii). folic acid-conjugated poly(ethylene glycol) chains are embedded within the coordination polymer shell to achieve extended circulation and targeted delivery of probe particles in vivo. control of fe3o4 core grain sizes results in optimal r(2) relaxivity (224.5 x 10(-3) m-1 s(-1)) for t-2-weighted magnetic resonance imaging. cy-gd-iii coordination polymers are also regulated to obtain a maximum 25.1% of cy ligands and 5.2% of gd-iii ions for near-infrared fluorescence and t-1-weighted magnetic resonance imaging, respectively. the results demonstrate their impressive abilities for targeted, multimodal, and reliable imaging.
WOS关键词	MRI CONTRAST AGENTS ; COLLOIDAL PARTICLES ; FLUORESCENT DYES ; DRUG-RELEASE ; CANCER-CELLS ; DESIGN ; PROBES
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000364692700009
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176464
专题	高能物理研究所
通讯作者	Chen, Chunying
作者单位	1.Fudan Univ, Dept Macromol Sci, Collaborat Innovat Ctr Polymers & Polymer Composi, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	An, Qiao,Liu, Jing,Yu, Meng,et al. Multifunctional magnetic gd3+-based coordination polymer nanoparticles: combination of magnetic resonance and multispectral optoacoustic detections for tumor-targeted imaging in vivo[J]. Small,2015,11(42):5675-5686.
APA	An, Qiao.,Liu, Jing.,Yu, Meng.,Wan, Jiaxun.,Li, Dian.,...&Guo, Jia.(2015).Multifunctional magnetic gd3+-based coordination polymer nanoparticles: combination of magnetic resonance and multispectral optoacoustic detections for tumor-targeted imaging in vivo.Small,11(42),5675-5686.
MLA	An, Qiao,et al."Multifunctional magnetic gd3+-based coordination polymer nanoparticles: combination of magnetic resonance and multispectral optoacoustic detections for tumor-targeted imaging in vivo".Small 11.42(2015):5675-5686.

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