| Hybrid mesoporous silica-based drug carrier nanostructures with improved degradability by hydroxyapatite | |
| Hao, Xiaohong1; Hu, Xixue2; Zhang, Cuimiao1; Chen, Shizhu1; Li, Zhenhua1; Yang, Xinjian1; Liu, Huifang1; Jia, Guang1; Liu, Dandan1; Ge, Kun1 | |
| 刊名 | Acs nano
 |
| 2015-10-01 | |
| 卷号 | 9期号:10页码:9614-9625 |
| 关键词 | Silica/hydroxyapatite hybrid nanoparticles Biodegradability Ph sensitivity Anticancer drug carrier |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/nn507485j |
| 通讯作者 | Jia, guang(guangjia2001@163.com) |
| 英文摘要 | Potential bioaccumulation is one of the biggest limitations for silica nanodrug delivery systems in cancer therapy. in this study, a mesoporous silica nanoparticles/hydroxyapatite (msns/hap) hybrid drug carrier, which enhanced the biodegradability of silica, was developed by a one-step method. the morphology and structure of the nanoparticles were characterized by tem, dls, ft-ir, xrd, n-2 adsorption desorption isotherms, and xps, and the drug loading and release behaviors were tested. tem and icp-oes results indicate that the degradability of the nanoparticles has been significantly improved by ca2+ escape from the skeleton in an acid environment. the msns/hap sample exhibits a higher drug loading content of about 5 times that of msns. the biological experiment results show that the msns/hap not only exhibits good bioconnpatibility and antitumor effect but also greatly reduces the side effects of free dox. the as-synthesized hybrid nanoparticles may act as a promising drug delivery system due to their good biocompatibility, high drug loading efficiency, ph sensitivity, and excellent biodegradability. |
| WOS关键词 | IN-VIVO ; CONTROLLED-RELEASE ; HEMOLYTIC-ACTIVITY ; CANCER-THERAPY ; DELIVERY-SYSTEM ; NANOPARTICLES ; BIODISTRIBUTION ; LUMINESCENT ; PH ; BIOCOMPATIBILITY |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000363915300019 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2176458 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Jia, Guang |
| 作者单位 | 1.Hebei Univ, Coll Chem & Environm Sci, Chem Biol Key Lab Hebei Prov, Key Lab Med Chem & Mol Diag,Minist Educ, Baoding 071002, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hao, Xiaohong,Hu, Xixue,Zhang, Cuimiao,et al. Hybrid mesoporous silica-based drug carrier nanostructures with improved degradability by hydroxyapatite[J]. Acs nano,2015,9(10):9614-9625. |
| APA | Hao, Xiaohong.,Hu, Xixue.,Zhang, Cuimiao.,Chen, Shizhu.,Li, Zhenhua.,...&Zhang, Jinchao.(2015).Hybrid mesoporous silica-based drug carrier nanostructures with improved degradability by hydroxyapatite.Acs nano,9(10),9614-9625. |
| MLA | Hao, Xiaohong,et al."Hybrid mesoporous silica-based drug carrier nanostructures with improved degradability by hydroxyapatite".Acs nano 9.10(2015):9614-9625. |
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