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	Using a peptide segment to covalently conjugate doxorubicin and taxol for the study of drug combination effect
	Ling, Ya1; Gao, Yuan2; Shu, Chang1; Zhou, Ying1; Zhong, Wenying1,3; Xu, Bing4
刊名	Rsc advances
	2015
卷号	5期号:123页码:101475-101479
ISSN号	2046-2069
DOI	10.1039/c5ra14156g
通讯作者	Zhong, wenying(wyzhong@cpu.edu.cn)
英文摘要	Doxorubicin (dox) and taxol can be covalently bonded to the same peptide segment via proper structural modification. doxorubicin-maleimide derivative links to peptide via michael addition reaction and taxol-succi-nhs active ester connects to the same peptide backbone through ester-amide exchange reaction. enzymatic transformation, as an inherent biological process, is applied here to trigger the formation of nanofiber networks from the as prepared hydrogelator precursor. the precursor which loads equal molar ratio of dox and taxol can self-assemble to form a red stable hydrogel after dephosphorylation reaction catalyzed by alkaline phosphatase (alp). this hydrogel could maintain sustained release of drugs and show strong anticancer effect. this work, as a new strategy to build a codelivery system of covalently linked dox and taxol, owns the potential to serve as an injectable hydrogel for therapeutic applications.
WOS关键词	METASTATIC BREAST-CANCER ; CO-DELIVERY ; ANTITUMOR EFFICACY ; IN-VITRO ; PACLITAXEL ; HYDROGELS ; INHIBITION ; NANOPARTICLES ; STABILITY ; SYSTEM
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000365952200031
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176436
专题	高能物理研究所
通讯作者	Zhong, Wenying
作者单位	1.China Pharmaceut Univ, Dept Analyt Chem, Nanjing, Jiangsu, Peoples R China 2.Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.China Pharmaceut Univ, Key Lab Biomed Funct Mat, Nanjing 210009, Peoples R China 4.Brandeis Univ, Dept Chem, Waltham, MA 02454 USA
推荐引用方式 GB/T 7714	Ling, Ya,Gao, Yuan,Shu, Chang,et al. Using a peptide segment to covalently conjugate doxorubicin and taxol for the study of drug combination effect[J]. Rsc advances,2015,5(123):101475-101479.
APA	Ling, Ya,Gao, Yuan,Shu, Chang,Zhou, Ying,Zhong, Wenying,&Xu, Bing.(2015).Using a peptide segment to covalently conjugate doxorubicin and taxol for the study of drug combination effect.Rsc advances,5(123),101475-101479.
MLA	Ling, Ya,et al."Using a peptide segment to covalently conjugate doxorubicin and taxol for the study of drug combination effect".Rsc advances 5.123(2015):101475-101479.

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