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	Imaging-guided combined photothermal and radiotherapy to treat subcutaneous and metastatic tumors using iodine-131-doped copper sulfide nanoparticles
	Yi, Xuan1,2; Yang, Kai1,2; Liang, Chao3,4; Zhong, Xiaoyan1,2; Ning, Ping1,2; Song, Guosheng3,4; Wang, Dongliang5; Ge, Cuicui1,2; Chen, Chunying5; Chai, Zhifang1,2
刊名	Advanced functional materials
	2015-08-05
卷号	25期号:29页码:4689-4699
关键词	Cancer metastasis Copper sulfide Multimodal imaging Photothermal therapy Radiotherapy
ISSN号	1616-301X
DOI	10.1002/adfm.201502003
通讯作者	Yi, xuan()
英文摘要	Combining different therapeutic strategies to treat cancer by overcoming limitations of conventional cancer therapies has shown great promise in both fundamental and clinical studies. herein, by adding i-131 when making iodine-doped cus nanoparticles, cus/[i-131]i nanoparticles are obtained, which after functionalization with polyethylene glycol (peg) are used for radiotherapy (rt) and photothermal therapy (ptt), by utilizing their intrinsic high near-infrared absorbance and the doped i-131-radioactivity, respectively. the combined rt and ptt based on cus/[i-131]i-peg is then conducted, achieving remarkable synergistic therapeutic effects as demonstrated in the treatment of subcutaneous tumors. in the meanwhile, as revealed by bimodal nuclear imaging and computed tomography (ct) imaging, it is found that cus/[i-131]i-peg nanoparticles after being injected into primary solid tumors could migrate to and retain in their nearby sentinel lymph nodes. importantly, the combined rt and ptt applied on those lymph nodes to assist surgical resection of primary tumors results in remarkably inhibited cancer metastasis and greatly prolonged animal survival. in vivo toxicology studies further reveal that our cus/i-peg is not obviously toxic to animals at fourfold of the treatment dose. this work thus demonstrates the potential of combining rt and ptt using a single nanoagent for imaging-guided treatment of metastatic tumors.
WOS关键词	WALLED CARBON NANOTUBES ; NANO-GRAPHENE OXIDE ; IN-VIVO ; CANCER-CELLS ; GOLD NANORODS ; BIOMEDICAL APPLICATIONS ; CONVERSION EFFICIENCY ; LYMPHATIC METASTASIS ; OPTICAL-PROPERTIES ; THERANOSTIC AGENT
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000359025700015
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176415
专题	高能物理研究所
通讯作者	Yi, Xuan
作者单位	1.Soochow Univ, Sch Radiat Med & Protect, Collaborat Innovat Ctr Radiat Med, Coll Med,Jiangsu Higher Educ Inst, Suzhou 215123, Jiangsu, Peoples R China 2.Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med, Coll Med,Jiangsu Higher Educ Inst, Suzhou 215123, Jiangsu, Peoples R China 3.Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China 4.Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Jiangsu, Peoples R China 5.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Yi, Xuan,Yang, Kai,Liang, Chao,et al. Imaging-guided combined photothermal and radiotherapy to treat subcutaneous and metastatic tumors using iodine-131-doped copper sulfide nanoparticles[J]. Advanced functional materials,2015,25(29):4689-4699.
APA	Yi, Xuan.,Yang, Kai.,Liang, Chao.,Zhong, Xiaoyan.,Ning, Ping.,...&Liu, Zhuang.(2015).Imaging-guided combined photothermal and radiotherapy to treat subcutaneous and metastatic tumors using iodine-131-doped copper sulfide nanoparticles.Advanced functional materials,25(29),4689-4699.
MLA	Yi, Xuan,et al."Imaging-guided combined photothermal and radiotherapy to treat subcutaneous and metastatic tumors using iodine-131-doped copper sulfide nanoparticles".Advanced functional materials 25.29(2015):4689-4699.

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