QQ客服 官方微博 反馈留言

	Ph-sensitive polymeric nanoparticles with gold(i) compound payloads synergistically induce cancer cell death through modulation of autophagy
	Lin, Yao-Xin1,2; Gao, Yu-Juan1; Wang, Yi1,2; Qiao, Zen-Ying1; Fan, Gang1; Qiao, Sheng-Lin1,2; Zhang, Ruo-Xin1; Wang, Lei1; Wang, Hao1
刊名	Molecular pharmaceutics
	2015-08-01
卷号	12期号:8页码:2869-2878
关键词	Autophagy Ros Ph-sensitive Polymer Nanoparticles Cancer
ISSN号	1543-8384
DOI	10.1021/acs.molpharmaceut.5b00060
通讯作者	Wang, hao(wanghao@nanoctr.cn)
英文摘要	Various nanomaterials have been demonstrated as autophagy inducers owing to their endocytosis cell uptake pathway and impairment of lysosomes. ph-dependent nanomaterials as drug delivery systems that are capable of dissociating in weakly acidic lysosomal environment (ph 45) and consequently releasing the payloads into the cytoplasm have been paid extensive attention, but their autophagy-modulating effects are less reported so far. in this study, we report ph-sensitive micelle-like nanoparticles (nps) that self-assembled from poly(beta-amino ester)s to induce cell autophagy. by encapsulation of gold(i) compounds (au(i)) into hydrophobic domains of nps, the resultant au(i)-loaded nps (au(i)subset of nps) shows synergistic cancer cell killing performance. the au(i)subset of nps enter cells through endocytosis pathway and accumulate into acidic lysosomes. subsequently, the protonation of tertiary amines of poly(beta-amino ester)s triggers the dissociation of micelles, damages the lysosomes, and blocks formation of autolysosomes from fusion of lysosomes with autophagosomes. in addition, au(i) preferentially inhibits thioredoxin reductase (trxr) in mcf-7 human breast cancer cells that directly links to up-regulate reactive oxygen species (ros) and consequently induce autophagy and apoptosis. the blockade of autophagy leads to excessive depletion of cellular organelles and essential proteins and ultimately results in cell death. therefore, ph-sensitive polymeric nanoparticles with gold(i) compound payloads can synergistically induce cancer cell death through regulation of autophagy. identification of the ph-sensitive nanomaterials for synergistically inducing cell death through regulation autophagy may open a new avenue for cancer therapy.
WOS关键词	INTRACELLULAR DRUG-DELIVERY ; ORTHO ESTER GROUPS ; THERAPEUTIC APPLICATIONS ; POLY(BETA-AMINO ESTER)S ; OLIGO(ETHYLENE GLYCOL) ; THIOREDOXIN REDUCTASE ; TRIGGERED RELEASE ; ANTICANCER DRUGS ; CYSTIC-FIBROSIS ; QUANTUM DOTS
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS类目	Medicine, Research & Experimental ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000359096100029
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176413
专题	高能物理研究所
通讯作者	Wang, Hao
作者单位	1.Chinese Acad Sci, Key Lab Biol Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol NCNST, Beijing, Peoples R China 2.Univ Chinese Acad Sci UCAS, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Lin, Yao-Xin,Gao, Yu-Juan,Wang, Yi,et al. Ph-sensitive polymeric nanoparticles with gold(i) compound payloads synergistically induce cancer cell death through modulation of autophagy[J]. Molecular pharmaceutics,2015,12(8):2869-2878.
APA	Lin, Yao-Xin.,Gao, Yu-Juan.,Wang, Yi.,Qiao, Zen-Ying.,Fan, Gang.,...&Wang, Hao.(2015).Ph-sensitive polymeric nanoparticles with gold(i) compound payloads synergistically induce cancer cell death through modulation of autophagy.Molecular pharmaceutics,12(8),2869-2878.
MLA	Lin, Yao-Xin,et al."Ph-sensitive polymeric nanoparticles with gold(i) compound payloads synergistically induce cancer cell death through modulation of autophagy".Molecular pharmaceutics 12.8(2015):2869-2878.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。