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	Facile fabrication of rare-earth-doped gd2o3 hollow spheres with upconversion luminescence, magnetic resonance, and drug delivery properties
	Tian, Gan1,3; Gu, Zhanjun1; Liu, Xiaoxiao1; Zhou, Liangjun1; Yin, Wenyan1; Yan, Liang1; Jin, Shan1,4; Ren, Wenlu1; Xing, Gengmei1; Li, Shoujian3
刊名	Journal of physical chemistry c
	2011-12-08
卷号	115期号:48页码:23790-23796
ISSN号	1932-7447
DOI	10.1021/jp209055t
通讯作者	Gu, zhanjun(zjgu@ihep.ac.cn)
英文摘要	Rare-earth (re)-doped gadolinium oxide (gd2o3) hollow nanospheres have been successfully prepared on a large scale via a template-directed method using hydrothermal carbon spheres as sacrificed templates. scanning electron microscope and transmission electron microscope images reveal that these hollow-structured nanosphere spheres have the mesoporous shells that are composed of a large amount of uniform nanoparticles. by doping the re ions (yb/er) into the gd2o3 host matrix, these nps emitted bright multicolored upconversion emissions that can be fine-tuned from green to red by adjusting the codoped yb/er ratio under 980 nm nir laser excitation. the possibility of using these upconversion nanoparticles for optical imaging in vivo has been demonstrated. it was also shown that these gd2o3 nanospheres brightened the t-1-weighted images and enhanced the r(1) relaxivity of water protons, which suggested that they could act as t-1 contrast agents for magnetic resonance (mr) imaging. moreover, these hollow spheres can be used as drug delivery host carriers, and drug storage/release properties were investigated using ibuprofen as the model drug. as a result, the so-prepared nanoscaled gd2o3 hollow spheres bearing upconversion luminescence, mr imaging, and drug delivery capabilities could be potentially employed for simultaneous mr/fluorescent imaging and therapeutic applications.
WOS关键词	SILICA NANOSPHERES ; CONTRAST AGENT ; NANOCRYSTALS ; NANOPARTICLES ; TEMPLATES ; EMISSION ; CARRIERS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目	Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000297446300020
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176222
专题	高能物理研究所
通讯作者	Gu, Zhanjun
作者单位	1.Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 2.Natl Ctr Nanosci & Technol China, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Sichuan Univ, Coll Chem, Chengdu 610064, Peoples R China 4.Chinese Acad Sci, Grad Univ, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Tian, Gan,Gu, Zhanjun,Liu, Xiaoxiao,et al. Facile fabrication of rare-earth-doped gd2o3 hollow spheres with upconversion luminescence, magnetic resonance, and drug delivery properties[J]. Journal of physical chemistry c,2011,115(48):23790-23796.
APA	Tian, Gan.,Gu, Zhanjun.,Liu, Xiaoxiao.,Zhou, Liangjun.,Yin, Wenyan.,...&Zhao, Yuliang.(2011).Facile fabrication of rare-earth-doped gd2o3 hollow spheres with upconversion luminescence, magnetic resonance, and drug delivery properties.Journal of physical chemistry c,115(48),23790-23796.
MLA	Tian, Gan,et al."Facile fabrication of rare-earth-doped gd2o3 hollow spheres with upconversion luminescence, magnetic resonance, and drug delivery properties".Journal of physical chemistry c 115.48(2011):23790-23796.

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