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	Highly sensitive and selective dna-based detection of mercury(ii) with alpha-hemolysin nanopore
	Wen, Shuang1; Zeng, Tao2; Liu, Lei1; Zhao, Kai1; Zhao, Yuliang1,2; Liu, Xianjin3; Wu, Hai-Chen1
刊名	Journal of the american chemical society
	2011-11-16
卷号	133期号:45页码:18312-18317
ISSN号	0002-7863
DOI	10.1021/ja206983z
通讯作者	Zhao, yuliang(zhaoyuliang@ihep.ac.cn)
英文摘要	The duplex formation mediated by hg(2+) in a properly designed ssdna generates a stable hairpin structure, which greatly alters the translocation profile of the ssdna through a-hemolysin nanopore. from the 2d-events contour plot, the presence of hg(2+) can be confirmed in as little as 30 min at similar to 7 nm or higher. the sensor is highly selective to hg(2+), without interference from other metal ions. it can be fabricated from readily available materials, without the processes of synthesis, purification, probe-making, and so forth. this sensing strategy opens new possibilities for detecting many types of analytes which have specific interactions with dna molecules.
WOS关键词	DOUBLE-STRANDED DNA ; MERCURIC ION ; AQUEOUS-MEDIA ; HG2+ IONS ; FLUORESCENT CHEMOSENSOR ; TURN-ON ; MICROCANTILEVER SENSORS ; SENSING MERCURY(II) ; GOLD NANOPARTICLES ; QUANTUM DOTS
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000297381200056
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2176054
专题	高能物理研究所
通讯作者	Zhao, Yuliang
作者单位	1.Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 2.Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China 3.Jiangsu Acad Agr Sci, Key Lab Food Qual & Safety Jiangsu Prov, Key Lab Agrofood Safety & Qual, State Key Lab Breeding Base,Minist Agr,Inst Food, Nanjing 210014, Peoples R China
推荐引用方式 GB/T 7714	Wen, Shuang,Zeng, Tao,Liu, Lei,et al. Highly sensitive and selective dna-based detection of mercury(ii) with alpha-hemolysin nanopore[J]. Journal of the american chemical society,2011,133(45):18312-18317.
APA	Wen, Shuang.,Zeng, Tao.,Liu, Lei.,Zhao, Kai.,Zhao, Yuliang.,...&Wu, Hai-Chen.(2011).Highly sensitive and selective dna-based detection of mercury(ii) with alpha-hemolysin nanopore.Journal of the american chemical society,133(45),18312-18317.
MLA	Wen, Shuang,et al."Highly sensitive and selective dna-based detection of mercury(ii) with alpha-hemolysin nanopore".Journal of the american chemical society 133.45(2011):18312-18317.

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